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Invitrogen
PCGF6 Polyclonal Antibody
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Product Details
PA5-76818
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant full length Human PCGF6.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Polycomb group (PcG) proteins form multiprotein complexes that regulate expression patterns of developmental and cell proliferation genes. Several members of the PcG contain ring finger domains and are identified as a subclass of RING finger proteins. The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain the RING-type zinc finger conserved domain are generally involved in the ubiquitination pathway of protein degradation. PCGF6 (polycomb group ring finger 6), also known as MBLR or RNF134, is a 350 amino acid nuclear protein that is ubiquitously expressed and contains one RING-type zinc finger. PCGF6 acts as a transcriptional repressor and regulates the level of histone H3K4Me3 by activating SmcY histone demethylase. PCGF6 exists as two alternatively spliced isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hMBLR; Mel18 and Bmi1-like RING finger; Mel18 and Bmi1-like RING finger protein; Mel18- and Bmi1-like RING finger protein; Polycomb group RING finger protein 6; RING finger protein 134; unnamed protein product
Gene Aliases: 4933407A11Rik; AI604840; MBLR; PCGF6; RNF134
UniProt ID: (Human) Q9BYE7, (Rat) Q5XI70, (Mouse) Q99NA9
Entrez Gene ID: (Human) 84108, (Rat) 309457, (Mouse) 71041
protein binding
zinc ion binding
metal ion binding
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
molecular_function
DNA binding
transcription factor activity, sequence-specific DNA binding
protein domain specific binding
histone modifying enzyme
negative regulation of transcription from RNA polymerase II promoter
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
transcription, DNA-templated
transcription from RNA polymerase II promoter
biological_process
regulation of transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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