Search
Invitrogen
Optineurin Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 7
Optineurin Antibody (PA5-78311) in ICC/IF
Immunofluorescence analysis of Optineurin was performed using 70 percent confluent log phase A-431 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with Optineurin Polyclonal Antibody (Product # PA5-78311) at 1:200 in 0.1% BSA, incubated at 4 degree cel... View More
Product Details
PA5-78311
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human Optineurin. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.62 mg/mL
Amount
162 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: 293T, A431, HeLa, HepG2, mouse eye
Predicted Reactivity: Pig (82%), Rhesus Monkey (92%), Bovine (81%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14. 7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Ag9 C5; E3-14.7K-interacting protein; FIP 2; FIP-2; FIP-2; HYPL; NRP; TFIIIA-INTP; RAB8-INTP; E3-14.7K-INTP; HIP 7; HIP-7; Huntingtin interacting protein L; Huntingtin yeast partner L; Huntingtin-interacting protein 7; Huntingtin-interacting protein L; interacts with adenovirus E3-14.7KDa, a TNF-alpha cytolysis antagonist; NEMO-related protein; Optic neuropathy-inducing protein; Optineurin; TFIIIA IntP; TFIIIA-INTP; Transcription factor IIIA-interacting protein; transcrption factor IIIA-interacting protein; tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains; Uban; unnamed protein product
Gene Aliases: 4930441O07Rik; ALS12; FIP2; GLC1E; HIP7; HYPL; NRP; OPTN; TFIIIA-INTP
UniProt ID: (Human) Q96CV9, (Mouse) Q8K3K8
Entrez Gene ID: (Human) 10133, (Mouse) 71648
negative regulation of receptor recycling
immune system process
autophagy
Golgi organization
signal transduction
protein localization
cell death
positive regulation of autophagy
protein localization to Golgi apparatus
cellular response to unfolded protein
Golgi to plasma membrane protein transport
regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
defense response to Gram-negative bacterium
parkin-mediated mitophagy in response to mitochondrial depolarization
Golgi ribbon formation
positive regulation of xenophagy
protein targeting to Golgi
positive regulation of cell proliferation
macroautophagy
cellular protein localization
negative regulation of neuron apoptotic process
cytokine secretion
protein homooligomerization
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support