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Invitrogen
GAB2 Polyclonal Antibody
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FIGURE: 1 / 1
GAB2 Antibody (PA5-88958) in WB
Western blot analysis of GAB2 in extracts of various cell lines. Samples were incubated with GAB2 Polyclonal antibody (Product # PA5-88958) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
Product Details
PA5-88958
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 377-676 of human GAB2 (NP_5367391)
Conjugate
Form
Liquid
Concentration
0.37 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ENSRSVAATI PRRNTLPAMD NSRLHRASSC ETYEYPQRGG ESAGRSAESM SDGVGSFLPG KMIVGRSDST NSEDNYVPMN PGSSTLLAME RAGDNSQSVY IPMSPGAHHF DSLGYPSTTL PVHRGPSRGS EIQPPPVNRN LKPDRKAKPT PLDLRNNTVI DELPFKSPIT KSWSRANHTF NSSSSQYCRP ISTQSITSTD SGDSEENYVP MQNPVSASPV PSGTNSPAPK KSTGSVDYLA LDFQPSSPSP HRKPSTSSVT SDEKVDYVQV DKEKTQALQN TMQEWTDVRQ SSEPSKGAKL; Positive Samples: HeLa, Mouse kidney; Cellular Location: Cell membrane, Cytoplasm
Target Information
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Grb2 associated binder 2; GRB2-associated binder 2; GRB2-associated-binding protein 2; GRB3-3; Growth factor receptor bound protein 2-associated protein 2; PH domain-containing adaptor molecule p97; pp100
Gene Aliases: AI463667; D130058I17Rik; GAB2; KIAA0571; p97
UniProt ID: (Human) Q9UQC2
Entrez Gene ID: (Human) 9846, (Mouse) 14389
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
osteoclast differentiation
positive regulation of mast cell degranulation
protein kinase B signaling
integrin-mediated signaling pathway
positive regulation of signal transduction
cell migration
intracellular signal transduction
phosphatidylinositol-mediated signaling
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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