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Invitrogen
DST Polyclonal Antibody
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FIGURE: 1 / 1
DST Antibody (PA5-96034) in WB
Western blot analysis of DST in extracts of various cell lines. Samples were incubated with DST Polyclonal antibody (Product # PA5-96034) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-96034
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
0.97 mg/mL
Amount
97 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MHSSSYSYRS SDSVFSNTTS TRTSLDSNEN LLLVHCGPTL INSCISFGSE SFDGHRLEML QQIANRVQRD SVICEDKLIL AGNALQSDSK RLESGVQFQN EAEIAGYILE CENLLRQHVI DVQILIDGKY YQADQLVQRV AKLRDEIMAL RNECSSVYSK GRILTTEQTK LMISGITQSL NSGFAQTLHP SLTSGLTQSL TPSLTSSSMT SGLSSGMTSR LTPSVTPAYT PGFPSGLVPN FSSGVEPNSL QTLKLMQIRK PLLKSSLLDQ; Positive Samples: THP-1, Rat kidney; Cellular Location: Cell junction, Cell membrane, Cell projection, Cytoplasm, Endoplasmic reticulum membrane, H zone, Lipid-anchor, Membrane, Nucleus, Nucleus envelope, Single-pass membrane protein, Z line, axon, cell cortex, cytoskeleton, cytoskeleton, hemidesmosome, myofibril, sarcomere
Target Information
As basal cells of stratified squamous epithelia begin to migrate in response to wound healing, they lose their cell-substrate adhesion junctions, the hemidesmosomes. The hemidesmosome is an adhesion structure of the epidermal-dermal junction in keratinocytes. When keratinocytes migrate laterally or upward to differentiate they must control the formation and disintegration of the hemidesmosomes. The bullous pemphigoid antigen BPAG1 is a hemidesmosomal protein of the cutaneous basement membrane zone. The primary sequence deduced from full-length human cDNAs predicts that this molecule consists of a central rod region and flanking globular domains. A neuronal isoform, BPAG1n3 is the result of differential splicing of BPAG1. BPAG1n3 is distinguished by its initial 32 amino acid residues and by the absence of the amino-terminal half of the actin-binding domain.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 230 kDa bullous pemphigoid antigen; 230/240 kDa bullous pemphigoid antigen; BPA; BPAG1eA; MACF-like product; BPAG1eB; second IF-binding domain product; bullous pemphigoid antigen; Bullous pemphigoid antigen 1; bullous pemphigoid antigen 1, isoform 5; bullous pemphigoid antigen 1, isoforms 1/2/3/4; bullous pemphigoid antigen 1, isoforms 6/7; Dystonia musculorum protein; Dystonin; Hemidesmosomal plaque protein; Microtubule actin cross-linking factor 2; trabeculin-beta; unnamed protein product
Gene Aliases: 2310001O04Rik; A830042E19Rik; ah; athetoid; AW554249; BP230; BP240; BPA; Bpag; BPAG1; BPAG1-n; CATX-15; CATX15; D6S1101; DMH; DST; DT; EBS3; EBSB2; HSAN6; KIAA0728; MACF2; mKIAA0728; nmf203; nmf339
UniProt ID: (Human) Q03001, (Mouse) Q91ZU6
Entrez Gene ID: (Human) 667, (Mouse) 13518, (Rat) 316313
microtubule cytoskeleton organization
cytoskeleton organization
cell adhesion
integrin-mediated signaling pathway
retrograde axonal transport
response to wounding
maintenance of cell polarity
hemidesmosome assembly
wound healing
intermediate filament cytoskeleton organization
cell motility
cell cycle arrest
axonogenesis
regulation of microtubule polymerization or depolymerization
cytoplasmic microtubule organization
intracellular transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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