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          System Message

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          LOADING ...
          See other LEP SIRNA Assays ›
          Gene Symbol:
          Lep
          Gene Name:
          leptin
          Gene Aliases:
          OB, obese
          Chromosome Location:
          Chr.4: 56337695 - 56351818 on Build Rnor_6.0
          UniGene ID:
          Rn.44444
          Species:
          Rat
          Species Specific ID (Flybase ID):
          -
          siRNA ID 197683

          Purification
          Size
          Availability Inventoried
          Catalog # AM16708
          Price 4,126.00
          Your Price
          Online offer:
          4126.0
          Check your price ›
          • Genomic Map
          • siRNA Details
          • More Information

          Genomic Map

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          siRNA Details

          Gene Symbol: Lep
          Interrogated Sequence Translated Protein Targeted Exon(s) siRNA Location IMAGE Clone ID
          RefSeq NM_013076.3 NP_037208.1 1 148
          XM_008762762.1 XP_008760984.1 1 236
          GenBank mRNA D45862.1 - 2 160
          D49653.1 - 1 129
          S78586.1 - 1 100
          U48849.1 - 1 61

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          More Information


          Other Species Targeted

          This siRNA also targets the following transcripts in Human: NM_000230, U18915, BC069323, BC060830, U43653, and others.
          This siRNA also targets the following transcripts in Mouse: NM_008493, HQ166716, FJ374142, AK030984, BC125245, and others.

          Panther Classification:

          Molecular Function -

          peptide hormone

          Gene Ontology Categories:

          Function(s) Process(es)

          negative regulation of transcription from RNA polymerase II promoter
          ovulation from ovarian follicle
          response to hypoxia
          positive regulation of cytokine production
          placenta development
          regulation of protein phosphorylation
          response to dietary excess
          cardiac muscle hypertrophy
          glucose metabolic process
          regulation of gluconeogenesis
          energy reserve metabolic process
          glycerol biosynthetic process
          lipid metabolic process
          fatty acid beta-oxidation
          JAK-STAT cascade
          tyrosine phosphorylation of STAT protein
          female pregnancy
          response to nutrient
          circadian rhythm
          cholesterol metabolic process
          bile acid metabolic process
          regulation of blood pressure
          positive regulation of cell proliferation
          adult feeding behavior
          fatty acid catabolic process
          negative regulation of metabolic process
          regulation of metabolic process
          cAMP-mediated signaling
          central nervous system neuron development
          insulin secretion
          regulation of intestinal cholesterol absorption
          negative regulation of appetite
          response to insulin
          response to vitamin E
          leptin-mediated signaling pathway
          positive regulation of luteinizing hormone secretion
          positive regulation of peroxisome proliferator activated receptor signaling pathway
          intracellular signal transduction
          bone mineralization involved in bone maturation
          positive regulation of protein import into nucleus
          hormone metabolic process
          positive regulation of tyrosine phosphorylation of Stat3 protein
          glucose homeostasis
          eating behavior
          negative regulation of apoptotic process
          positive regulation of ion transport
          positive regulation of MAPK cascade
          regulation of fat cell differentiation
          positive regulation of myeloid cell differentiation
          negative regulation of vasoconstriction
          positive regulation of JAK-STAT cascade
          positive regulation of insulin receptor signaling pathway
          positive regulation of follicle-stimulating hormone secretion
          positive regulation of developmental growth
          regulation of insulin secretion
          regulation of steroid biosynthetic process
          leukocyte tethering or rolling
          regulation of lipoprotein lipid oxidation
          adipose tissue development
          negative regulation of cartilage development
          negative regulation of glucagon secretion
          cellular response to L-ascorbic acid
          cellular response to retinoic acid
          regulation of protein localization to nucleus
          positive regulation of STAT protein import into nucleus
          positive regulation of reactive oxygen species metabolic process
          negative regulation of glutamine transport
          positive regulation of hepatic stellate cell activation
          cytokine activity
          hormone activity
          growth factor activity
          peptide hormone receptor binding

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          Host server : magellan-search-blue-55ff9ddd88-49ts5:80/100.66.72.225:80.
          git-commit: d366ff9721d93504b2ac26a183b2b3e3d0e7d9ec
          git-url: https://github.com/thermofisher/magellan-search
          git-branch: release/2.42.0-2026.01.03-1.0