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          System Message

          OKCancel
          LOADING ...
          See other LEP SIRNA Assays ›
          Gene Symbol:
          Lep
          Gene Name:
          leptin
          Gene Aliases:
          ob, obese
          Chromosome Location:
          Chr.6: 29060195 - 29073877 on Build GRCm38
          UniGene ID:
          Mm.277072
          Species:
          Mouse
          Species Specific ID (Flybase ID):
          -
          siRNA ID s69164

          Purification
          Size
          Availability Made To Order
          Catalog # 4390771
          Price 5,354.00
          Your Price
          Online offer:
          5354.0
          Check your price ›
          • Genomic Map
          • siRNA Details
          • More Information

          Genomic Map

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          siRNA Details

          Gene Symbol: Lep
          Interrogated Sequence Translated Protein Targeted Exon(s) siRNA Location IMAGE Clone ID
          RefSeq NM_008493.3 NP_032519.1 2 189
          GenBank mRNA AK030984.1 - 2 189
          AK142589.1 - 2 192
          BC125245.1 - 1 160 40054245
          FJ374142.1 - 1 130
          HQ166716.1 - 2 189
          U18812.1 - 2 186

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          More Information


          Other Species Targeted

          This siRNA also targets the following transcripts in Human: NM_000230, U18915, BC069323, BC060830, U43653, and others.
          This siRNA also targets the following transcripts in Rat: NM_013076, XM_008762762, D49653, D45862, U48849, and others.

          Panther Classification:

          Molecular Function -

          peptide hormone

          Gene Ontology Categories:

          Function(s) Process(es)

          negative regulation of transcription from RNA polymerase II promoter
          ovulation from ovarian follicle
          placenta development
          regulation of protein phosphorylation
          response to dietary excess
          cardiac muscle hypertrophy
          glucose metabolic process
          regulation of gluconeogenesis
          energy reserve metabolic process
          glycerol biosynthetic process
          lipid metabolic process
          fatty acid beta-oxidation
          signal transduction
          tyrosine phosphorylation of STAT protein
          cholesterol metabolic process
          bile acid metabolic process
          regulation of blood pressure
          positive regulation of cell proliferation
          adult feeding behavior
          fatty acid catabolic process
          negative regulation of metabolic process
          regulation of metabolic process
          central nervous system neuron development
          insulin secretion
          regulation of intestinal cholesterol absorption
          negative regulation of appetite
          response to insulin
          leptin-mediated signaling pathway
          positive regulation of peroxisome proliferator activated receptor signaling pathway
          intracellular signal transduction
          bone mineralization involved in bone maturation
          positive regulation of protein import into nucleus
          hormone metabolic process
          positive regulation of tyrosine phosphorylation of Stat3 protein
          glucose homeostasis
          eating behavior
          negative regulation of apoptotic process
          positive regulation of ion transport
          positive regulation of MAPK cascade
          regulation of fat cell differentiation
          positive regulation of myeloid cell differentiation
          negative regulation of vasoconstriction
          positive regulation of JAK-STAT cascade
          positive regulation of insulin receptor signaling pathway
          positive regulation of developmental growth
          regulation of insulin secretion
          regulation of steroid biosynthetic process
          leukocyte tethering or rolling
          regulation of lipoprotein lipid oxidation
          adipose tissue development
          negative regulation of cartilage development
          negative regulation of glucagon secretion
          regulation of protein localization to nucleus
          positive regulation of STAT protein import into nucleus
          positive regulation of reactive oxygen species metabolic process
          negative regulation of glutamine transport
          positive regulation of hepatic stellate cell activation
          hormone activity
          protein binding
          growth factor activity
          peptide hormone receptor binding

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          Host server : magellan-search-green-55658555d6-qfdf2:80/100.66.76.55:80.
          git-commit: ec8e7df5f8fec8d765bd419205f1b5046a016d37
          git-url: https://github.com/thermofisher/magellan-search
          git-branch: release/2.41.0-Offline