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          System Message

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          LOADING ...
          See other PARK2 SIRNA Assays ›
          Gene Symbol:
          Park2
          Gene Name:
          Parkinson disease (autosomal recessive, juvenile) 2, parkin
          Gene Aliases:
          PRKN
          Chromosome Location:
          Chr.17: 10840384 - 12063370 on Build GRCm38
          UniGene ID:
          Mm.311110
          Species:
          Mouse
          Species Specific ID (Flybase ID):
          -
          siRNA ID s78529

          Purification
          Size
          재고 정보 주문접수 후 제작
          Catalog # 4390771
          제품 정가 5,354.00
          Your Price
          온라인 행사가:
          5354.0
          공급가 확인 ›
          • Genomic Map
          • siRNA Details
          • More Information

          Genomic Map

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          siRNA Details

          Gene Symbol: Park2
          Interrogated Sequence Translated Protein Targeted Exon(s) siRNA Location IMAGE Clone ID
          RefSeq NM_016694.3 NP_057903.1 2 188
          GenBank mRNA AB019558.1 - 2 159
          AF250293.1 - 2 188
          AF250294.1 - 2 188
          AF250295.1 - 2 188
          BC113204.1 - 2 171 40047891
          FJ555555.1 - 1 159
          FJ555556.1 - 2 159
          FJ555557.1 - 2 159
          GU272056.1 - 1 159

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          추가 정보


          Other Species Targeted

          This siRNA also targets the following transcripts in Rat: NM_020093, GU322363, AB039878, AF168004, AF381280, and others.

          Gene Ontology Categories:

          Function(s) Process(es)

          protein polyubiquitination
          mitophagy
          negative regulation of protein phosphorylation
          synaptic transmission, dopaminergic
          startle response
          transcription, DNA-templated
          regulation of transcription, DNA-templated
          protein monoubiquitination
          autophagy
          response to unfolded protein
          learning
          locomotory behavior
          adult locomotory behavior
          proteasomal protein catabolic process
          regulation of autophagy
          positive regulation of gene expression
          negative regulation of gene expression
          positive regulation of mitochondrial fusion
          regulation of mitochondrion organization
          protein ubiquitination
          protein metabolic process
          regulation of protein ubiquitination
          negative regulation of actin filament bundle assembly
          positive regulation of proteasomal ubiquitin-dependent protein catabolic process
          negative regulation of glucokinase activity
          response to endoplasmic reticulum stress
          synaptic transmission, glutamatergic
          regulation of dopamine metabolic process
          norepinephrine metabolic process
          dopamine metabolic process
          protein ubiquitination involved in ubiquitin-dependent protein catabolic process
          positive regulation of I-kappaB kinase/NF-kappaB signaling
          proteasome-mediated ubiquitin-dependent protein catabolic process
          positive regulation of DNA binding
          negative regulation of neuron apoptotic process
          cellular protein catabolic process
          negative regulation by host of viral genome replication
          positive regulation of transcription from RNA polymerase II promoter
          negative regulation of insulin secretion
          regulation of neurotransmitter secretion
          modulation of synaptic transmission
          protein stabilization
          positive regulation of neurotransmitter uptake
          dopamine uptake involved in synaptic transmission
          mitochondrion localization
          protein autoubiquitination
          regulation of mitochondrial membrane potential
          negative regulation of cell death
          protein K63-linked ubiquitination
          protein localization to mitochondrion
          aggresome assembly
          protein K48-linked ubiquitination
          protein K11-linked ubiquitination
          protein K6-linked ubiquitination
          negative regulation of release of cytochrome c from mitochondria
          cellular response to toxic substance
          mitophagy in response to mitochondrial depolarization
          regulation of cellular response to oxidative stress
          negative regulation of neuron death
          positive regulation of proteasomal protein catabolic process
          negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
          negative regulation of primary amine oxidase activity
          positive regulation of protein linear polyubiquitination
          negative regulation of oxidative stress-induced neuron death
          regulation of protein targeting to mitochondrion
          positive regulation of tumor necrosis factor-mediated signaling pathway
          negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
          positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
          negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
          positive regulation of dendrite extension
          negative regulation of spontaneous neurotransmitter secretion
          regulation of reactive oxygen species metabolic process
          negative regulation of reactive oxygen species metabolic process
          G-protein coupled receptor binding
          actin binding
          ubiquitin-protein transferase activity
          protein binding
          zinc ion binding
          UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
          tubulin binding
          ligase activity
          ribosomal S6-glutamic acid ligase activity
          enzyme binding
          kinase binding
          protein kinase binding
          PDZ domain binding
          Hsp70 protein binding
          heat shock protein binding
          ubiquitin conjugating enzyme binding
          ubiquitin protein ligase binding
          protein complex binding
          identical protein binding
          histone deacetylase binding
          ubiquitin binding
          phospholipase binding
          coenzyme F420-0 gamma-glutamyl ligase activity
          coenzyme F420-2 alpha-glutamyl ligase activity
          metal ion binding
          chaperone binding
          ubiquitin protein ligase activity
          protein-glycine ligase activity
          protein-glycine ligase activity, initiating
          protein-glycine ligase activity, elongating
          tubulin-glycine ligase activity
          protein-glutamic acid ligase activity
          tubulin-glutamic acid ligase activity
          cullin family protein binding
          ubiquitin-specific protease binding
          F-box domain binding

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          관련 제품

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          • Invivofectamine 2.0
          • Lipofectamine™ 2000 Transfection Reagent
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