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Gibco
Human EPO (Erythropoietin) Recombinant Protein
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Product Details
PHC9631
Product Specifications
Species
Human
Expression System
CHO cells
Molecular weight
18.4 kDa
Class
Recombinant
Type
Protein
Purity
≥95% by SDS-PAGE
Endotoxin concentration
<0.1 ng/µg
Activity
ED50 ≤ 0.8 ng/mL; determined by the dose-dependent proliferation of TF-1 cells.
Conjugate
Form
Lyophilized
Purification
purified
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Wet ice
Product Specific Information
Carrier-Free
Reconstitution: Centrifuge the vial briefly, prior to opening to bring the contents to the bottom. Reconstitute the lyophilized protein in sterile water to a concentration of 0.1-1 mg/mL to regain full activity. Apportion the reconstituted protein into working aliquots and store at ≤-20°C. Make any further dilutions of the reconstituted protein in medium or buffered solution containing carrier protein, such as PBS with 0.1% BSA.
Storage: Store lyophilized human EPO 2°C to 8°C, preferably desiccated. Store reconstituted human EPO at ≤-20°C (not in a frost-free freezer). Keep freeze-thaw cycles to a minimum.
Target Information
Erythropoietin (EPO) protein is a growth factor essential for the survival, proliferation, and differentiation of erythroid precursors. EPO is not responsible for early commitment to the lineage, and instead induces the final maturation of partially differentiated erythroid cells and the production of red cell-specific proteins, such as hemoglobin. The EPO receptor (EPOR) is present in higher levels on precursor cells, and expression diminishes with cell maturation.Hepatocytes are the main source of EPO in the fetus, followed by interstitial cells of the kidney after birth and through adulthood. EPO expression is upregulated during hypoxia, and low levels of transcription have also been detected in lung and brain tissue under these conditions. Recent data suggest that EPO may also play a role in the protection of neuronal tissue from damage and initiation of repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epoetin; Erythropoietin; MGC138142
Gene Aliases: EP; EPO; MVCD2
UniProt ID: (Human) P01588
Entrez Gene ID: (Human) 2056
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