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Product Details
PEP-005
Product Specifications
Species Reactivity
Mouse
Class
Synthetic
Type
Peptide
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
purified
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
PEP-005 is a synthetic peptide whose sequence is from the C-terminal end of the mouse retinoic acid receptor beta (RAR*). The 21 amino acid sequence extends from amino acids 429 to 448 of RAR*. The sequence of PEP-005 is (amino to carboxy terminus): P S V S P S S V E N S G V S Q S P L L Q (The N-terminal cysteine has been added to facilitate conjugation and is not a part of the native mouse RAR* sequence)
This peptide may be used for neutralization and control experiments with the monoclonal and polyclonal antibodies that reacts with this product and the human and mouse RAR*, catalog # MA1-811 and PA1-811. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.
Reconstitute with 0.1 mL of distilled water.
Target Information
Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Nuclear receptor subfamily 1 group B member 2; RAR beta; RAR-b; RAR-beta; RAR-Beta2; RAR-Beta4; retinoic acid; retinoic acid receptor; Retinoic acid receptor beta
Gene Aliases: A830025K23; Hap; Nr1b2; Rarb
UniProt ID: (Mouse) P22605
Entrez Gene ID: (Mouse) 218772
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