Advanced biological image analysis across the life sciences

Explore the diverse applications of Thermo Scientific Amira Software across various scientific fields. From cell biology and anatomical biology to neuroscience, pharma and biotech, structural biology, plant biology, and bioengineering, Amira Software provides powerful tools for visualization, analysis, and data integration. Discover how Amira Software enhances research and development in these disciplines by offering advanced capabilities tailored to meet the specific needs of each field.


Cell biology

Amira Software simplifies the analysis of complex imaging data, offering insights beyond 2D images. It can automatically separate and measure cells and nuclei in 3D, detect cellular features, reduce noise, and increase contrast for high-resolution models. It supports multi-modal imaging with flexible registration tools, processes large multichannel and time series data without size or memory limits via the Xplore5D extension, and automatically detects and traces filaments, reconstructs networks, and quantifies parameters like length and thickness. Correlative studies are enabled through intermodal registration methods, proven effective across various life sciences applications.

Entire Chlamydomonas imaged under cryogenic conditions. AI Deep Learning segmentation identified various organelles.

Anatomical biology

Amira Software provides a flexible, unified framework for scientists in biomedical and pharmaceutical research, allowing seamless registration of multiple imaging modalities and correlative analysis at single time points or across longitudinal studies. Widely used in publications and high-throughput analysis, it is an ideal choice for tissue investigation, brain research, dental research, and other applications. It supports bone analysis according to research community guidelines and offers advanced digital volume correlation for studying deformation and strain in materials. Amira Software excels in visualizing, segmenting, and analyzing large datasets with conventional and AI-integrated solutions, making it invaluable for preclinical and clinical research imaging.

Trabecular bone Murine tibial - Herbst et al, R. Soc. open sci. 2021.

Neuroscience

Amira Software is a crucial tool for neuroscientists, providing comprehensive solutions for analyzing complex neural data across various scales and modalities. It processes large multichannel datasets from light sheet or confocal microscopy without size or memory limitations, and features AI segmentation, filament detection, and network reconstruction to reduce manual effort and increase productivity.

 

Amira Software offers advanced tools for CT and MRI/DTI data, including brain atlas creation, neuronal connectivity tracing, and robust image registration.

 

Enhanced visualization options support grayscale images and tensor fields, utilizing established algorithms to advance our understanding of brain connectivity.

Brain MRI image visualized with Amira Software.

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Pharmaceuticals and biotechnology

Amira Software helps the pharmaceutical and biotechnology industries tackle challenges like condensed R&D timelines, complex datasets, and the need for automation. It provides tools for visualizing, segmenting, and understanding complex life science data from various imaging modalities.

 

With advanced imaging analysis, deep learning models for automated segmentation, and compatibility with high-content screening platforms, Amira Software aids in drug discovery, target identification, and preclinical research. Thermo Fisher Scientific offers support and customization services to enhance the software's effectiveness, speeding up drug discovery and improving the understanding of biological systems.

Prednisilone tablet visualized with Amira Software

Structural biology

Amira Software helps the pharmaceutical and biotechnology industries tackle challenges like condensed R&D timelines, complex datasets, and the need for automation. It provides tools for visualizing, segmenting, and understanding complex life science data from various imaging modalities.

 

With advanced imaging analysis, deep learning models for automated segmentation, and compatibility with high-content screening platforms, Amira Software aids in drug discovery, target identification, and preclinical research. Thermo Fisher Scientific offers support and customization services to enhance the software's effectiveness, speeding up drug discovery and improving the understanding of biological systems.

Actin filaments. Dr. Marion Jasnin, Department of Molecular Structural Biology, Max Planck Institute for Biochemistry, Martinsried, Germany. Original publication of data: Jasnin et al. 2019. Structure. DOI: https://doi.org/10.1016/j.str.2019.05.009

Plant biology

Amira Software helps plant biology researchers visualize and analyze complex plant structures at cellular and subcellular levels with high precision and efficient data integration. It provides automated workflows for plant tissue analysis, including roots, stems, leaves, and cellular structures.

 

With powerful segmentation tools and integrated AI solutions, Amira Software enhances data processing accuracy and speed, surpassing traditional methods. It also integrates multimodal imaging data for seamless correlation of different data types, essential for tracking growth patterns, studying cellular responses to environmental stimuli, and understanding plant-microbe interactions.

3D thylakoids and pyrenoids with Amira Software.

Bioengineering and biomaterial

Amira Software addresses the labor-intensive task of bone segmentation for bioengineers by offering semi-automated and fully automated workflows, including specialized workflows for cortical and trabecular bone segmentation. Developed over nearly two decades, this robust framework continuously improves to meet researchers' needs.

 

Amira Software also supports digital volume correlation (DVC), allowing researchers to measure non-contact, 3D volumetric displacement and strain data within biological tissues and implants. This capability is essential for studying the mechanical properties of bones and understanding strain transfer and failure mechanisms.

Weight-bearing CT imaging combined with digital volume correlation. Courtesy St Luke’s Radiology Oxford Ltd UK, Imperial College London UK, 3Dmagination Ltd UK.

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For Research Use Only. Not for use in diagnostic procedures.