We have developed a unique portfolio of affinity resins to help you develop biosimilars, biobetters, and other types of recombinant proteins. These affinity resins can be used for clinical and commercial production and include:

  • Unique resins to purify only intact FSH by binding to the alpha/beta chain interface
  • Albumin resins offering high capacity and mild elution conditions needed for albumin fusion proteins

In addition to affinity resins, we also offer product-specific ELISAs to measure any ligand potentially leaching from the column.

The graphic below depicts a typical workflow in which CaptureSelect resin can be used for a primary capture step for the efficient production of recombinant proteins.

  • Selectivity─high purity in single step/feed-stock independent
  • Mild elution conditions─retention of biological activity of target
  • Reduction of process steps─helps reduce costs, allows higher yields
  • Efficient clearance of HCP, DNA, virus─high selectivity in capture step

CaptureSelect affinity matrices:

Product Target applications Uniqueness RoboColumn™ format
CaptureSelect Follicle Stimulating Hormone (FSH) Human follicle stimulating hormone Binds only intact FSH due to alpha/beta chain epitope  
CaptureSelect Human Albumin Human serum albumin, albumin fusion proteins Mild elution conditions help to protect fusion partner X
CaptureSelect hCG Binds to the alpha chain of hCG (human chorionic gonadotropin) Selective for hCG, with cross-binding to LH, FSH, and TSH  
CaptureSelect tPA Human tissue plasminogen activator (tPA) The only tPA affinity resin available on the market  
CaptureSelect C-tagXL Binds the short C-tag sequence E-P-E-A (glutamic acid - proline - glutamic acid – alanine) when this affinity tag is fused at the C-terminus of a target protein Optimized to obtain high yields in protein purification  

Quantitate the yield of your proteins during the production process with our analytical columns or develop your own analytical assay with CaptureSelect Ligand Conjugates.

When your specific process needs cannot be met with current products, our custom chromatography services are available to build you a unique solution. For more information, please visit Custom Capabilities .

CaptureSelect Leakage ELISAs

Products incorporating CaptureSelect technology are used for clinical and commercial manufacturing of a variety of biologicals. To support these products, Thermo Fisher Scientific has developed product-specific Leakage ELISAs that can be used for routine quality analysis. Below is a list of Leakage ELISAs and their corresponding affinity resins.

Product Complementing resin
CaptureSelect FSH Ligand Leakage ELISA CaptureSelect Follicle Stimulating Hormone (FSH) Affinity Matrix
CaptureSelect HSA Ligand Leakage ELISA CaptureSelect Human Albumin Affinity Matrix
CaptureSelect hCG Ligand Leakage ELISA CaptureSelect hCG Affinity Matrix
CaptureSelect tPA Ligand Leakage ELISA CaptureSelect tPA Affinity Matrix
CaptureSelect C-tagXL Ligand Leakage ELISA CaptureSelect C-tagXL Affinity Matrix
CaptureSelect tPA Ligand Leakage ELISA CaptureSelect tPA Affinity Matrix
CaptureSelect VII Select Leakage ELISA Kit VIISelect *
CaptureSelect VIII Select Leakage ELISA Kit VIIISelect *
CaptureSelect IX Select Leakage ELISA Kit IXSelect *
CaptureSelect GCSFSelect Leakage ELISA Kit GCSFSelect *
CaptureSelect Alpha-1 Antitrypsin Select Leakage ELISA Kit Alpha-1 Antitrypsin Select *

* Complementing resins are available through GE Healthcare Life Sciences

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Contact us for more information about CaptureSelect technologies.

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