Her-4, also known as c-erbB-4 and v-erbB-4, is a Type 1 membrane protein found in numerous cell types. It is a member of the EGF receptor protein family, and is activated by neuregulins and NTAK. Her-4 levels have been found to be elevated in certain human tumor cell lines suggesting that it may play a role in some malignancies. Her-4 is a receptor for heregulin and is capable of mediating HGL-stimulated tyrosine phosphorylation of itself.
avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; Avian erythroblastic leukemia viral (verbb2) oncogene homolog 4; avian erythroblastosis oncogene B 4; C-erbB-4; ERBB4; ERBB4 transcript variant I12DEL; ERBB4 transcript variant I20DEL; human epidermal growth factor receptor 4; p180erbB4; Proto-oncogene-like protein c-ErbB-4; Receptor tyrosine-protein kinase erbB-4; Tyrosine kinase type cell surface receptor HER4; Tyrosine kinase-type cell surface receptor HER4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4; Verb a e
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