Synaptophysin is a calcium-binding and integral membrane glycoprotein present in presynaptic vesicles in almost all neurons. Synaptophysin has four transmembrane domains and it forms a complex with dynamin at high calcium concentrations suggesting an involvement in synaptic vesicle endocytosis.
Synaptophysin is currently the most widely used marker for nerve terminals and for differentiating neuroendocrine tumors.
BM89 antigen; Major synaptic vesicle protein p38; Synaptophysin; Syp I
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