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Antibodies Inc
JIP-2/IB-2 Monoclonal Antibody (N135/37), FL550
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Product Details
75-163-FL550
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N135/37
Immunogen
Fusion protein amino acids 226-421 of mouse JIP-2/IB-2 (accession number Q9ERE9) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
550/575 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-Jun-amino-terminal kinase-interacting protein 2; IB 2; IB-2; Islet brain 2; Islet-brain-2; JIP 2; JIP-2; JNK MAP kinase scaffold protein 2; JNK-interacting protein 2; mitogen activated protein kinase 8 interacting protein 2; Mitogen-activated protein kinase 8-interacting protein 2
Gene Aliases: 3230402N03Rik; AI847694; AW049958; IB2; Jip2; Mapk8ip2; R75148
UniProt ID: (Mouse) Q9ERE9, (Rat) G3V9M2
Entrez Gene ID: (Mouse) 60597, (Rat) 315220
MAPK cascade
behavioral fear response
JNK cascade
mating behavior
regulation of receptor activity
positive regulation of stress-activated MAPK cascade
social behavior
positive regulation of protein kinase activity
regulation of JNK cascade
nonassociative learning
dendrite morphogenesis
regulation of synaptic transmission, glutamatergic
excitatory postsynaptic potential
regulation of N-methyl-D-aspartate selective glutamate receptor activity
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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