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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 708-927 of human GBA2 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
2.19 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2805134 |
Immunogen sequence: AQDIQDKFSS ILSRGQEAYE RLLWNGRYYN YDSSSRPQSR SVMSDQCAGQ WFLKACGLGE GDTEVFPTQH VVRALQTIFE LNVQAFAGGA MGAVNGMQPH GVPDKSSVQS DEVWVGVVYG LAATMIQEGL TWEGFQTAEG CYRTVWERLG LAFQTPEAYC QQRVFRSLAY MRPLSIWAMQ LALQQQQHKK ASWPKVKQGT GLRTGPMFGP KEAMANLSPE; Positive Samples: U-87MG, Mouse kidney, Mouse heart; Cellular Location: Cytoplasmic side, Endoplasmic reticulum membrane, Golgi apparatus membrane, Peripheral membrane protein
Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo. Plays a role in central nevous system development. Required for proper formation of motor neuron axons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 3.2.1.45; Beta-glucocerebrosidase 2; Beta-glucosidase 2; bile acid; Bile acid beta-glucosidase GBA2; Bile acid glucosyl transferase GBA2; Cholesterol glucosyltransferase GBA2; Cholesteryl-beta-glucosidase GBA2; glucosidase, beta (bile acid) 2; Glucosylceramidase 2; NLGase; Non-lysosomal glucosylceramidase
Gene Aliases: AD035; F630034E04; GBA2; KIAA1605; NLGase; SPG46
UniProt ID: (Human) Q9HCG7, (Mouse) Q69ZF3
Entrez Gene ID: (Human) 57704, (Mouse) 230101
Molecular Function:
glucosidase
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