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Search Thermo Fisher Scientific
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:500-1:2,000 | View 3 publications 3 publications |
Immunohistochemistry (IHC) |
Assay-dependent | View 1 publication 1 publication |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
Product Specifications | |
---|---|
Species Reactivity |
Human |
Published species |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
INSR Fusion Protein Ag13922 (980-1382 aa encoded by BC117172) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.25 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: RKRQPDGPL GPLYASSNPE YLSASDVFPC SVYVPDEWEV SREKITLLRE LGQGSFGMVY EGNARDIIKG EAETRVAVKT VNESASLRER IEFLNEASVM KGFTCHHVVR LLGVVSKGQP TLVVMELMAH GDLKSYLRSL RPEAENNPGR PPPTLQEMIQ MAAEIADGMA YLNAKKFVHR DLAARNCMVA HDFTVKIGDF GMTRDIYETD YYRKGGKGLL PVRWMAPESL KDGVFTTSSD MWSFGVVLWE ITSLAEQPYQ GLSNEQVLKF VMDGGYLDQP DNCPERVTDL MRMCWQFNPK MRPTFLEIVN LLKDDLHPSF PEVSFFHSEE NKAPESEELE MEFEDMENVP LDRSSHCQRE EAGGRDGGSS LGFKRSYEEH IPYTHMNGGK KNGRILTLPR SNPS (980-1382 aa encoded by BC117172)
INSR (insulin receptor, IR) is a heterodimeric protein complex that has an intracellular beta subunit and an extracellular alpha subunit, which is disulfide- linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intracellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD 220; CD220; CD220 antigen; CD220 beta; HHF 5; Insulin receptor; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR 1; IR beta; IR-1; IR1
Gene Aliases: CD220; HHF5; INSR
UniProt ID: (Human) P06213
Entrez Gene ID: (Human) 3643
Molecular Function:
transmembrane signal receptor
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