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Invitrogen
CaV3.1 Monoclonal Antibody (N178A/9), FITC
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FIGURE: 1 / 3
CaV3.1 Antibody (MA5-45544) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis using human neuroblastoma cells. Fixation involved 4% Formaldehyde for 15 min at RT. Samples were incubated with Cav3.1 monoclonal antibody (Product # MA5-45544) at 1:100 for 60 min at RT, followed by Goat Anti-Mouse ATTO 488 at 1:200 for 60 min at RT. Counterstain used was Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1,000, 1:5,000 for 60 min at RT, 5 min at RT. Localization: Cell Membrane, Membrane, Cytoplasm, Nucleoplasm. Magnification: 60X. (A) DAPI (blue) nuclear st... View More
Product Details
MA5-45544
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N178A/9
Immunogen
Fusion protein amino acids 2052-2172 (cytoplasmic C-terminus) of mouse Cav3.1
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
9.1mM sodium bicarbonate/PBS, pH 7.4, with 640.91mM DMSO, 136.36mM ethanolamine
Contains
no preservative
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
1 µg/mL of MA5-45544 was sufficient for detection of Cav3.1 in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately <200kDa. Does not cross-react with Cav3.2.
This antibody was formerly sold as clone S178A-9
Target Information
Voltage-dependent Ca2+ channels mediate Ca2+ entry into excitable cells in response to membrane depolarization, and they are involved in a variety of Ca2+-dependent processes, including muscle contraction, hormone or neurotransmitter release and gene expression. Calcium channels are highly diverse, multimeric complexes composed of an alpha-1 subunit, an intracellular beta subunit, a disulfide linked alpha-2/delta subunit and a transmembrane gamma subunit. Ca2+ currents are characterized on the basis of their biophysical and pharmacologic properties and include L-, N-, T-, P-, Q-, and R- types. T-type Ca2+ currents are activated and inactivated more rapidly and at more negative membrane potentials than other Ca2+ current types. T-type Ca2+ channels enhance odor sensitivity by lowering the threshold of spike generation in olfactory receptor cells (ORCs).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha1G-ae; Alpha1G-aef; Alpha1G-af; Alpha1G-bc; Alpha1G-bcd; Alpha1G-bce; Alpha1G-bcef; Alpha1G-be; CACNA1G-a; T-type; CACNA1G-b; T-type; calcium channel, voltage-dependent, T type, alpha 1G subunit; CaV T1; Cav3 1; cav3 1c; Cav3.1c; low voltage-activated T-type calcium channel alpha-1 subunit Cav3.1; low-voltage-activated calcium channel; MGC117234; NBR13; unnamed protein product; voltage-dependent calcium channel alpha 1G subunit; voltage-dependent T-type calcium channel alpha 1G subunit; Voltage-dependent T-type calcium channel subunit alpha-1G; voltage-gated calcium channel; Voltage-gated calcium channel subunit alpha Cav3.1
Gene Aliases: [a]1G; a1G; alpha-1G; Ca(V)T.1; CACNA1G; Cav3.1; Cav3.1d; KIAA1123; mKIAA1123; NBR13; SCA42; SCA42ND
UniProt ID: (Human) O43497
Entrez Gene ID: (Human) 8913, (Rat) 29717, (Mouse) 12291
ion channel activity
voltage-gated calcium channel activity
calcium channel activity
high voltage-gated calcium channel activity
low voltage-gated calcium channel activity
voltage-gated calcium channel activity involved in AV node cell action potential
voltage-gated calcium channel activity involved SA node cell action potential
scaffold protein binding
protein binding
voltage-gated ion channel
action potential
regulation of heart rate
sinoatrial node development
ion transport
calcium ion transport
chemical synaptic transmission
response to nickel cation
ion transmembrane transport
regulation of membrane potential
transmembrane transport
regulation of atrial cardiac muscle cell membrane depolarization
regulation of biological quality
calcium ion import
calcium ion transmembrane transport
cardiac muscle cell action potential involved in contraction
SA node cell action potential
AV node cell action potential
SA node cell to atrial cardiac muscle cell signalling
AV node cell to bundle of His cell signaling
membrane depolarization during AV node cell action potential
membrane depolarization during SA node cell action potential
regulation of heart rate by cardiac conduction
calcium ion import across plasma membrane
positive regulation of cytosolic calcium ion concentration
artery smooth muscle contraction
regulation of ion transmembrane transport
positive regulation of calcium ion-dependent exocytosis
regulation of calcium ion transport
calcium ion transport into cytosol
cellular response to dexamethasone stimulus
membrane depolarization during action potential
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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