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Invitrogen

CaV3.1 Monoclonal Antibody (N178A/9), PE

View all (18) CaV3.1 antibodies

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Product Details

MA5-45546

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

Assay-dependent
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

N178A/9

Immunogen

Fusion protein amino acids 2052-2172 (cytoplasmic C-terminus) of mouse Cav3.1

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA

Contains

no preservative

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2932000

Product Specific Information

1 µg/mL of MA5-45546 was sufficient for detection of Cav3.1 in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately <200kDa. Does not cross-react with Cav3.2.

This antibody was formerly sold as clone S178A-9.

Target Information

Voltage-dependent Ca2+ channels mediate Ca2+ entry into excitable cells in response to membrane depolarization, and they are involved in a variety of Ca2+-dependent processes, including muscle contraction, hormone or neurotransmitter release and gene expression. Calcium channels are highly diverse, multimeric complexes composed of an alpha-1 subunit, an intracellular beta subunit, a disulfide linked alpha-2/delta subunit and a transmembrane gamma subunit. Ca2+ currents are characterized on the basis of their biophysical and pharmacologic properties and include L-, N-, T-, P-, Q-, and R- types. T-type Ca2+ currents are activated and inactivated more rapidly and at more negative membrane potentials than other Ca2+ current types. T-type Ca2+ channels enhance odor sensitivity by lowering the threshold of spike generation in olfactory receptor cells (ORCs).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: a1G subunit; Alpha1G-ae; Alpha1G-aef; Alpha1G-af; Alpha1G-bc; Alpha1G-bcd; Alpha1G-bce; Alpha1G-bcef; Alpha1G-be; CACNA1G-a; T-type; CACNA1G-b; T-type; calcium channel, voltage-dependent, T type, alpha 1G subunit; CaV T1; Cav3 1; cav3 1c; cav3.1c; domain II-III linker; domain III-IV linker; domain IV; ion channel; Cav3.1; CACNA1G; low voltage-activated T-type calcium channel alpha-1 subunit Cav3.1; low-voltage-activated calcium channel; MGC117234; unnamed protein product; voltage-dependent calcium channel alpha 1G subunit; voltage-dependent T-type calcium channel alpha 1G subunit; voltage-gated calcium channel; voltage-gated calcium channel subunit alpha Cav3.1

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Gene Aliases: [a]1G; a1G; alpha-1G; Ca(V)T.1; Cav3.1; Cav3.1d; mKIAA1123; NBR13; SCA42; SCA42ND

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UniProt ID: (Human) O43497

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Entrez Gene ID: (Human) 8913, (Mouse) 12291, (Rat) 29717

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Function(s)
ion channel activity voltage-gated calcium channel activity high voltage-gated calcium channel activity low voltage-gated calcium channel activity voltage-gated calcium channel activity involved in AV node cell action potential voltage-gated calcium channel activity involved SA node cell action potential scaffold protein binding voltage-gated sodium channel activity protein binding
Process(es)
sinoatrial node development ion transport regulation of membrane potential transmembrane transport calcium ion import calcium ion transmembrane transport cardiac muscle cell action potential involved in contraction SA node cell action potential AV node cell action potential SA node cell to atrial cardiac muscle cell signalling AV node cell to bundle of His cell signaling membrane depolarization during AV node cell action potential membrane depolarization during SA node cell action potential regulation of heart rate by cardiac conduction calcium ion import across plasma membrane action potential regulation of heart rate system process positive regulation of cytosolic calcium ion concentration chemical synaptic transmission response to nickel cation artery smooth muscle contraction sodium ion transmembrane transport positive regulation of calcium ion-dependent exocytosis regulation of calcium ion transport regulation of atrial cardiac muscle cell membrane depolarization calcium ion transport into cytosol membrane depolarization during action potential cellular response to dexamethasone stimulus
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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