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Invitrogen
mGluR1/mGluR5 Monoclonal Antibody (N75/3), PerCP
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FIGURE: 1 / 3
mGluR1/mGluR5 Antibody (MA5-45582) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis using human neuroblastoma cells. Fixation involved 4% Formaldehyde for 15 min at RT. Samples were incubated with mGluR1/5 glutamate receptor monoclonal antibody (Product # MA5-45582) at 1:100 for 60 min at RT, followed by Goat Anti-Mouse ATTO 488 at 1:200 for 60 min at RT. Counterstain used was Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-45582
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
N75/3
Immunogen
Fusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b
Conjugate
PerCP
PerCP
PerCP
Excitation/Emission Max
482/675 nm
View spectra
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
1 µg/mL of MA5-45582 was sufficient for detection of mGluR1/5 glutamate receptor in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 130kDa (both mGluR1 and mGluR5).
This antibody was formerly sold as clone S75-3.
Target Information
may play a role in synaptic transmission; may interact with mGluR1, another group I metabotropic glutamate receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G protein coupled receptor family C group 1 member A; G protein-coupled receptor GRM5; G protein-coupled receptor, family C, group 1, member A; G protein-coupled receptor, family C, group 1, member E; glutamate receptor; glutamate receptor, metabotropic 1; glutamate receptor, metabotropic 5; GPCR family C; metabotropic glutamate receptor (mGluR5); metabotropic glutamate receptor 5b; metabotropic glutamate receptor subtype 5 homolog; metabotropic glutamate receptor subtype 5b; metabotropic glutamate receptor type 5; mGluR1; mGluR5; mGluR5f; mGluR5g; mGluR5h; mGluR5i; mGlurR1a; protein phosphatase 1, regulatory subunit 85; protein phosphatase 1, regulatory subunit 86; unnamed protein product; variant b of mGluR5
Gene Aliases: 4930455H15Rik; 6430542K11Rik; Glu5R; Gm10828; GPRC1A; GPRC1E; MGLU1; mGlu5; MGLUR1; MGLUR5; mGluR5b; nmf373; PPP1R85; PPP1R86; rcw; SCA44; SCAR13; wobl
UniProt ID: (Human) Q13255, (Human) P41594, (Rat) P23385, (Mouse) P97772, (Rat) P31424, (Mouse) Q3UVX5
Entrez Gene ID: (Human) 2911, (Human) 2915, (Rat) 24414, (Mouse) 14816, (Rat) 24418, (Mouse) 108071
adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
G-protein coupled receptor activity
protein binding
glutamate receptor activity
G protein-coupled neurotransmitter receptor activity
G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
protein tyrosine kinase activator activity
A2A adenosine receptor binding
identical protein binding
protein tyrosine kinase binding
PLC activating G-protein coupled glutamate receptor activity
fibronectin binding
collagen binding
estrogen receptor binding
laminin binding
protein sequestering activity
calmodulin binding
PDZ domain binding
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
chemical synaptic transmission
locomotory behavior
sensory perception of pain
regulation of membrane potential
positive regulation of MAPK cascade
regulation of sensory perception of pain
regulation of synaptic transmission, glutamatergic
regulation of postsynaptic membrane potential
synaptic signaling via neuropeptide
temperature homeostasis
response to amphetamine
desensitization of G-protein coupled receptor protein signaling pathway
regulation of transcription, DNA-templated
positive regulation of cytosolic calcium ion concentration
learning or memory
associative learning
positive regulation of dopamine secretion
operant conditioning
protein targeting to nuclear inner membrane
response to morphine
response to ethanol
response to antibiotic
positive regulation of long-term neuronal synaptic plasticity
synapse organization
positive regulation of calcium-mediated signaling
cognition
response to corticosterone
negative regulation of dendritic spine morphogenesis
sensory perception of hot stimulus
negative regulation of excitatory postsynaptic potential
positive regulation of cellular response to hypoxia
regulation of long term synaptic depression
positive regulation of intracellular signal transduction
positive regulation of sensory perception of pain
cellular response to beta-amyloid
conditioned place preference
positive regulation of neural precursor cell proliferation
protein phosphorylation
learning
phosphatidylinositol-mediated signaling
regulation of long-term neuronal synaptic plasticity
modulation of synaptic transmission
regulation of glutamate secretion
calcium-mediated signaling
positive regulation of cell migration
negative regulation of viral entry into host cell
receptor-mediated virion attachment to host cell
membrane depolarization
synaptic transmission, GABAergic
cellular response to electrical stimulus
L-glutamate import across plasma membrane
negative regulation of protein localization to plasma membrane
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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