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Invitrogen

mGluR1/mGluR5 Monoclonal Antibody (N75/3), PE

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mGluR1/mGluR5 Monoclonal Antibody (N75/3), PE

Product Details

MA5-45583

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

1:1,000
-

Immunocytochemistry (ICC/IF)

1:1,000
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

N75/3

Immunogen

Fusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b
3D Epitope / Immunogen

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA

Contains

no preservative

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2932037

Product Specific Information

1 µg/mL of MA5-45583 was sufficient for detection of mGluR1/5 glutamate receptor in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 130kDa (both mGluR1 and mGluR5).

This antibody was formerly sold as clone S75-3.

Target Information

may play a role in synaptic transmission; may interact with mGluR1, another group I metabotropic glutamate receptor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: G protein coupled receptor family C group 1 member A; G protein coupled receptor, family C, group 1, member A; G protein coupled receptor, family C, group 1, member E; G protein-coupled receptor GRM5; G protein-coupled receptor, family C, group 1, member A; G protein-coupled receptor, family C, group 1, member E; glutamate receptor; glutamate receptor, metabotropic 1; glutamate receptor, metabotropic 5; GPCR family C; metabotropic glutamate receptor (mGluR5); Metabotropic glutamate receptor 1; Metabotropic glutamate receptor 5; metabotropic glutamate receptor 5b; metabotropic glutamate receptor subtype 5 homolog; metabotropic glutamate receptor subtype 5b; metabotropic glutamate receptor type 5; mGluR1; mGluR5; mGluR5f; mGluR5g; mGluR5h; mGluR5i; mGlurR1a; protein phosphatase 1, regulatory subunit 85; protein phosphatase 1, regulatory subunit 86; unnamed protein product

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Gene Aliases: 4930455H15Rik; 6430542K11Rik; AI850523; ENSMUSG00000075319; Glu5R; Gm10828; GPRC1A; GPRC1E; GRM1; GRM5; MGLU1; mGlu5; MGLUR1; MGLUR5; mGluR5b; nmf373; PPP1R85; PPP1R86; rcw; SCA44; SCAR13; wobl

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UniProt ID: (Human) Q13255, (Human) P41594, (Mouse) P97772, (Rat) P23385, (Rat) P31424, (Mouse) Q3UVX5

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Entrez Gene ID: (Human) 2911, (Human) 2915, (Mouse) 14816, (Rat) 24414, (Rat) 24418, (Mouse) 108071

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Function(s)
adenylate cyclase inhibiting G-protein coupled glutamate receptor activity G-protein coupled receptor activity protein binding glutamate receptor activity G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration protein tyrosine kinase activator activity A2A adenosine receptor binding identical protein binding protein tyrosine kinase binding PLC activating G-protein coupled glutamate receptor activity signal transducer activity estrogen receptor binding calmodulin binding PDZ domain binding G-protein coupled receptor
Process(es)
signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled glutamate receptor signaling pathway G-protein coupled glutamate receptor signaling pathway chemical synaptic transmission locomotory behavior sensory perception of pain regulation of membrane potential positive regulation of MAPK cascade regulation of sensory perception of pain regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential cellular response to electrical stimulus L-glutamate import across plasma membrane synaptic signaling via neuropeptide regulation of postsynaptic cytosolic calcium ion concentration desensitization of G-protein coupled receptor protein signaling pathway regulation of transcription, DNA-templated learning or memory learning regulation of long-term neuronal synaptic plasticity positive regulation of long-term neuronal synaptic plasticity modulation of synaptic transmission synapse organization positive regulation of calcium-mediated signaling cognition positive regulation of intracellular signal transduction cellular response to beta-amyloid activation of MAPKK activity activation of MAPK activity protein kinase C-activating G-protein coupled receptor signaling pathway calcium-mediated signaling dimeric G-protein coupled receptor signaling pathway regulation of MAPK cascade positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway regulation of glutamate secretion membrane depolarization synaptic transmission, GABAergic activation of MAPKKK activity protein phosphorylation negative regulation of locomotion phosphatidylinositol-mediated signaling
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