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Invitrogen
SCN3B Monoclonal Antibody (N396/29), PE
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FIGURE: 1 / 3
SCN3B Antibody (MA5-45740) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis using human neuroblastoma cells. Fixation involved 4% Formaldehyde for 15 min at RT. Samples were incubated with Nav beta 3 monoclonal antibody (Product # MA5-45740) at 1:100 for 60 min at RT, followed by Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain used was Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1,000, 1:5,000 for 60 min RT, 5 min RT. Localization: Cell Membrane, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas R... View More
Product Details
MA5-45740
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
N396/29
Immunogen
Fusion protein amino acids 1-215 (full-length) of rat NavBeta3
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A 1:100 dilution of MA5-45740 was sufficient for detection of NavBeta3 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |Detects approximately 40kDa. Does not cross-reat with NavBeta1, Navbeta2, or Navbeta4.
This antibody was formerly sold as clone S396-29.
Target Information
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain and heart sodium channel beta 3 subunit; sodium channel beta 3 subunit; Sodium channel regulatory subunit beta-3; sodium channel subunit beta-3; sodium channel, voltage-gated, type III, beta subunit; unnamed protein product; voltage-gated sodium channel beta-3 subunit
Gene Aliases: 1110001K16Rik; 4833414B02Rik; ATFB16; BRGDA7; HSA243396; KIAA1158; SCN3B; SCNB3
UniProt ID: (Human) Q9NY72, (Mouse) Q8BHK2, (Rat) Q9JK00
Entrez Gene ID: (Human) 55800, (Mouse) 235281, (Rat) 245956
sodium channel activity
protein binding
sodium channel regulator activity
sodium channel inhibitor activity
ion channel binding
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
voltage-gated ion channel activity
molecular_function
ion channel
transporter
voltage-gated ion channel
ion transport
sodium ion transport
nervous system development
positive regulation of heart rate
positive regulation of sodium ion transport
ion transmembrane transport
sodium ion transmembrane transport
membrane depolarization
cardiac muscle contraction
regulation of atrial cardiac muscle cell membrane depolarization
regulation of ventricular cardiac muscle cell membrane depolarization
cardiac conduction
protein localization to plasma membrane
cardiac muscle cell action potential involved in contraction
ventricular cardiac muscle cell action potential
membrane depolarization during action potential
membrane depolarization during cardiac muscle cell action potential
atrial cardiac muscle cell action potential
SA node cell action potential
regulation of heart rate by cardiac conduction
transport
regulation of ion transmembrane transport
regulation of sodium ion transmembrane transporter activity
sensory perception of pain
SA node cell to atrial cardiac muscle cell communication
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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