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Invitrogen
ST2 Polyclonal Antibody
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FIGURE: 1 / 4
ST2 Antibody (PA5-47024) in IHC (P)
Immunohistochemical analysis of ST2 in immersion fixed paraffin-embedded sections of human liver . Samples were incubated with ST2 Polyclonal Antibody (Product # PA5-47024) using a dilution of 1.7 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG HRP Secondary Antibody. Tissue was stained with DAB (brown) and counterstained with hematoxylin (blue).
Product Details
PA5-47024
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Sf 21-derived recombinant human ST2/IL-1 R4 Lys19-Phe328
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, approximately 25% cross-reactivity with recombinant mouse (rm) ST2/IL-1 R4 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
IL-33R, also known as ST2, is a receptor for IL-33. It is a member of the IL-1 receptor family of innate receptors. Its extracellular domain consists of 3 Ig-like domains that directly interact with its co-receptor IL-1RAcP, and the ligand alarmin, IL-33. IL-33 ligation results in the association of IL-33R complex with its adaptor proteins MyD88, IRAK1, IRAK4 and TRAF6, and activation of the NF-kB, and MAPK pathways. This, in turn, instigates the release of chemokines and cytokines such as IL-5, IL-6, IL-8, and IL-13. Two most common isoforms of IL-33R that result from alternative splicing are ST2L - the membrane bound form, and ST2S - the soluble form. The membrane bound form can be released from the cell surface by proteolytic cleavage. The soluble forms have been suggested to act as decoys dampening the IL-33 signaling. IL-33R is primarily expressed by mast cells, basophils, and eosinophils. In mouse, IL-33R expression has been shown on ILC2 and Th2 cells. IL-33R signaling has been implicated in the number of immune conditions, including allergies, arthritis, atherosclerosis and sepsis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: growth stimulation-expressed; homolog of mouse growth stimulation-expressed; IL-1 R4; IL-1RL1; IL-33R; interleukin 1 receptor-like 1; interleukin 1 receptor-related protein; Interleukin-1 receptor-like 1; Interleukin1 receptor like 1; Protein ST2; sIL 33R; soluble IL 33 Receptor; soluble IL 33R
Gene Aliases: DER4; FIT-1; IL1RL1; IL33R; ST2; ST2L; ST2V; T1
UniProt ID: (Human) Q01638
Entrez Gene ID: (Human) 9173
negative regulation of T-helper 1 type immune response
immune response
signal transduction
negative regulation of cell proliferation
negative regulation of interferon-gamma production
positive regulation of interleukin-5 production
interleukin-33-mediated signaling pathway
positive regulation of macrophage activation
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of inflammatory response
positive regulation of chemokine secretion
cellular response to peptide
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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