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Ion GeneStudio features and integrated workflow
Powered by Ion Torrent technology, the Ion GeneStudio S5 systems are available as the Ion GeneStudio S5, S5 Plus, and S5 Prime, providing a range of sequencing speeds to choose from. With an expansive menu of applications and integration with automated library prep and data analysis, researchers can enjoy the benefit of an end-to-end NGS solution from a single supplier.
Key features of the Ion GeneStudio S5 system
The Ion GeneStudio S5 systems are designed to deliver fast, flexible, and scalable next-generation sequencing for targeted applications. Key features of the Ion GeneStudio S5 systems include:
| Automated library preparation | Ion Chef integration enables walk-away processing for amplification, enrichment, and chip loading |
| Fast turnaround time | Sequencing runs can be completed in as fast as 3 hours |
| Minimal hands-on time | As little as 45 minutes of manual interaction, depending on the application |
| Scalable throughput | Select from 6 different chips to match sequencing output to sample volume and assay requirements |
| Software integration | Plan, monitor, and transfer data from sequencing runs with Torrent Suite Software. Analyze data and interpret results data with Ion Reporter Software |
Sample-to-data workflow for the Ion GeneStudio S5 system
The Ion Chef System, GeneStudio S5 systems, and Ion Reporter Software are engineered to work together. This integrated workflow combines automated library preparation and templating, sequencing and an integrated suite of bioinformatics tools and pipelines to interpret results. With as little as 45 minutes of hands-on time and intuitive reagent setup, labs can move from sample to report with speed and convenience. This end-to-end solution simplifies complexity while supporting consistent results.
Sequencing flexibility that adjusts to your laboratory’s needs
How can a single instrument easily scale to accommodate multiple applications, throughputs, and data outputs? The answer is in the chip.
Ion Torrent sequencing chips help streamline your workflow while offering flexibility for a wide range of research applications. First, consider the number of samples you need to run and the desired data output that is optimal for your application. Then, simply select a sequencing chip that fits your throughput or application needs, ranging from 2 to 280 million reads per run.
This versatility enables you to run both small‑ and large‑scale projects without the need to change platforms.
Applications for the Ion GeneStudio System
Explore the wide range of applications supported by the Ion Torrent NGS Systems.
Cancer research
Enabling NGS analysis and discovery of multi-biomarker types (fusions, insertion/deletions (indels), single nucleotide variants, and copy number variations), Oncomine assays are part of an end-to-end workflow that includes simple, scalable sequencing with optimized bioinformatics and reporting—designed for cancer research.
Reproductive health research
Ion Torrent NGS solutions offer important scientific insight for future reproductive decisions.
Infectious disease and microbial research
Uncover microbial diversity, study pathogen outbreaks, and identify mutations that may be associated with antibiotic resistance. Take advantage of increased throughput, higher accuracy, and longer reads to produce rapid and accurate sequencing of microbes with streamlined sample preparation and a simple, scalable, and optimized data analysis workflow.
Complex and Inherited disease
Our complete NGS solutions are uniquely suited to research in understanding how the combination of genetics and the environment influence development of complex diseases such as autoimmune disorders, neurodegenerative diseases, and many others.
Human identification (HID)
Adopting targeted NGS for forensic DNA analysis and phenotyping in your laboratory is simpler than ever when you combine the Ion Chef System and Ion GeneStudio S5 Systems with optimized Precision ID library preparation, template preparation and sequencing kits, and forensically relevant panels.
Agrigenomics
Uncover traits to drive breeding decisions and help address the challenges of feeding a growing global population. Our instruments, reagents, and solutions for plant and animal genotyping applications enable simple, scalable, and affordable NGS that can help you drive remarkable agricultural innovations.
Ion AmpliSeq Designer
Don’t see your application listed above? Ion AmpliSeq Designer is an online primer design tool that lets you create custom panels for Ion Torrent next-generation sequencing. Researchers studying germline disorders can use this tool to create Ion AmpliSeq On-Demand panels from a catalog of pre-tested genes and receive them in smaller reaction sizes, so that they can iterate panel design with efficiency and convenience.
Ion GeneStudio frequently asked questions
The Ion GeneStudio S5 system is used for targeted next-generation sequencing (NGS) applications, including oncology research, reproductive health research, inherited disease analysis, and microbiome studies. It is designed to deliver fast, scalable sequencing with integrated data analysis, making it suitable for laboratories that need flexible throughput and rapid results.
The GeneStudio S5 system uses Ion Torrent semiconductor sequencing technology to detect hydrogen ions released during DNA synthesis. These signals are measured as changes in pH on a semiconductor chip and converted into digital sequencing data, eliminating the need for optical detection and enabling faster run times.
Sequencing run times on the GeneStudio S5 system typically range from a few hours to under a day, depending on the chip type and application. Many targeted sequencing workflows can be completed within the same day, including data analysis.
The GeneStudio S5 system can generate approximately 2 million to over 280 million reads per run, depending on the sequencing chip used. This chip-based scalability allows users to match throughput to their specific application needs.
The GeneStudio S5 workflow is highly automated when used with the Ion Chef system, which performs template preparation and chip loading. Hands-on time can be as low as 45 minutes, with most steps automated after run setup, enabling consistent and reproducible results.
For Research, Forensic, or Paternity Use Only. Not for use in diagnostic procedures.
PMR-005955