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Invitrogen
METAP1 Polyclonal Antibody
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Product Details
PA5-58202
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human METAP1. Recombinant protein control fragment (Product #RP-102796).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SVVRSYCGHG IHKLFHTAPN VPHYAKNKAV GVMKSGHVFT IEPMICEGGW QDETWPDGWT AVTRDGKRSA QFEH
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
Methionine aminopeptidase 1 (METAP1) is a gene located on chromosome 4q24, encoding an enzyme responsible for the removal of N-terminal methionine residues from newly synthesized proteins. METAP1 is essential for protein maturation and function, as the cleavage of methionine allows subsequent modifications that are crucial for protein stability and activity. This enzyme is ubiquitously expressed in various tissues and plays a significant role in post-translational modification processes, affecting cellular homeostasis and protein regulation. METAP1 is involved in several physiological pathways, including cell cycle progression, signal transduction, and stress response. Dysregulation of METAP1 activity can impact protein function and is associated with diseases like cancer, reflecting its importance in cellular proliferation and growth. Research into METAP1 focuses on its potential as a therapeutic target for modulating protein synthesis and its implications in diseases characterized by uncontrolled cell growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp781C0419; EC 3.4.11.18; KIAA0094MAP 1; MAP 1; MAP1; metAP 1; Methionine aminopeptidase 1; Peptidase M; Peptidase M 1
Gene Aliases: KIAA0094; MAP1A; METAP1; MetAP1A
UniProt ID: (Human) P53582
Entrez Gene ID: (Human) 23173
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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