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Invitrogen

IL-17A Recombinant Rabbit Monoclonal Antibody (4V7Y6)

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IL-17A Recombinant Rabbit Monoclonal Antibody (4V7Y6)

Product Details

MA5-51205

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

4V7Y6

Immunogen

Recombinant protein (or fragment)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.4 mg/mL

Amount

140 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3093028

Product Specific Information

Immunogen sequence: GITIPRNPGC PNSEDKNFPR TVMVNLNIHN RNTNTNPKRS SDYYNRSTSP WNLHRNEDPE RYPSVIWEAK CRHLGCINAD GNVDYHMNSV PIQQEILVLR REPPHCPNSF RLEKILVSVG CTCVTPIVHH VA

Target Information

Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; IL-17; ILN; inflammatory cytokine; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin-17; Interleukin-17A; Interleukin17A; R-IL-17-A

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Gene Aliases: CTLA-8; CTLA8; IL-17; IL-17A; IL17; IL17A; ILA17

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UniProt ID: (Human) Q16552

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Entrez Gene ID: (Human) 3605

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Function(s)
cytokine activity protein binding protein homodimerization activity protein heterodimerization activity
Process(es)
positive regulation of antimicrobial peptide production adaptive immune response immune system process apoptotic process inflammatory response immune response Notch signaling pathway cell-cell signaling cell death response to wounding gene expression positive regulation of keratinocyte proliferation keratinocyte differentiation positive regulation of interleukin-1 beta production positive regulation of interleukin-12 production positive regulation of interleukin-16 production positive regulation of interleukin-23 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production interleukin-17A-mediated signaling pathway keratinocyte proliferation innate immune response positive regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter defense response to Gram-negative bacterium defense response to Gram-positive bacterium defense response to fungus positive regulation of protein kinase B signaling intestinal epithelial structure maintenance cellular response to interleukin-1 fibroblast activation regulation of primary metabolic process interleukin-17-mediated signaling pathway granulocyte migration negative regulation of inflammatory response to wounding positive regulation of cytokine production involved in inflammatory response positive regulation of bicellular tight junction assembly positive regulation of tumor necrosis factor superfamily cytokine production negative regulation of interleukin-17-mediated signaling pathway positive regulation of chemokine (C-X-C motif) ligand 1 production
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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