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IL-17A Antibodies

Antibodies that detect IL-17A can be used in several scientific applications, including ELISA, Flow Cytometry, Western Blot, Immunohistochemistry and Immunocytochemistry. These antibodies target IL-17A in Human, Mouse, Rat and Non-human primate samples. Our IL-17A monoclonal, polyclonal and recombinant monoclonal antibodies are developed in Mouse, Rabbit, Rat and Goat. These antibodies have been verified by Neutralization and Cell treatment to confirm specificity to IL-17A. Find the IL-17A antibody that fits your needs. Choose from 1 of 146 IL-17A antibodies, which have been validated in experiments with 2520 publications and 1148 images featured in our data gallery.

Browse ... View more Antibodies that detect IL-17A can be used in several scientific applications, including ELISA, Flow Cytometry, Western Blot, Immunohistochemistry and Immunocytochemistry. These antibodies target IL-17A in Human, Mouse, Rat and Non-human primate samples. Our IL-17A monoclonal, polyclonal and recombinant monoclonal antibodies are developed in Mouse, Rabbit, Rat and Goat. These antibodies have been verified by Neutralization and Cell treatment to confirm specificity to IL-17A. Find the IL-17A antibody that fits your needs. Choose from 1 of 146 IL-17A antibodies, which have been validated in experiments with 2520 publications and 1148 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications.

Target Information

Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).

Synonyms

Ctla8; CTLA-8; cytokine; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; Il17; IL-17; IL17A; IL-17a; ILN; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17 precursor; interleukin 17A; interleukin-17; Interleukin17A; interleukin-17A; R-IL-17-A

Target Video

6320258477112

IL-17A antibodies from Thermo Fisher Scientific

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Learn more about IL-17A primary antibodies that can be used in ELISA, Flow Cytometry, Western Blot and Immunohistochemistry in Human, Mouse, Rat and Non-human primate samples.