Case Study

Sepsis: When Can I Safely Stop Antibiotics? 


Shawn Depcinski
PharmD
Antibiotic Stewardship



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Key Takeaways

Takeaway #1

Takeaway #1

National guidelines often provide ranges for antibiotic treatment duration for infectious diseases, such as limiting antibiotics to 4 days for patients with intra-abdominal infections that had adequate source control.1



Takeaway #2

Takeaway #2

It can be difficult to determine a patient-specific duration of therapy, and many providers err on the side of caution by prescribing at the upper range of recommended days of therapy.



Takeaway #3

Takeaway #3

Trending PCT can provide insight on an individual basis, regarding when the infection has resolved to the point where antibiotics can be safely discontinued.



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References
  1. Sawyer RG, Claridge JA, Nathens AB, et al. Short-course antimicrobial therapy for intraabdominal infection. New England Journal of Medicine. 2015;373(16):1577-1578. doi:10.1056/nejmc1508694