Learning Center

Ready for a deep dive?

Explore the most comprehensive procalcitonin (PCT) library, with more than 60 videos, webinars, case studies, and FAQs—as well as numerous guides, sample protocols, links to peer-reviewed studies, and more.

Quick links

Use the filters below to refine your search.



FILTERS Clear all
Clinical application
Disease state
Media Type
Special Patient Populations
Procalcitonin Aided Antibiotic Stewardship: The New Paradigm
Michael R. Broyles, PharmD.
Click here
Procalcitonin (PCT) improves antibiotic stewardship in SARS-CoV-2 treatment
Infographic of publications by Williams EJ et al and Peters C et al. on antibiotic stewardship in COVID-19 patients.
Click here
Interpretation of PCT and ANP in patients presenting with dyspnea in the emergency department – clinical cases
Interpretation of PCT and ANP in patients presenting with dyspnea in the emergency department – clinical cases
Click here
Biomarkers for antimicrobial stewardship: a reappraisal in COVID-19 times?
Van Berkel et al. Critical Care (2020).
Use of procalcitonin for antibiotic stewardship in patients with COVID-19: A quality improvement project in a district general hospital
Peters et al. Clinical Medicine 2020.
Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial
de Jong E et alLancet Infect Dis . 2016 Jul;.
Duration of antibiotic treatment using procalcitonin-guided treatment algorithms in older patients: a patient-level meta-analysis from randomized controlled trials
Age and Ageing May 2021.
Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials
Wirz, Y et al. Critical care (London, England) vol. 22,1 191. 15 Aug. 2018.
Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis
Schuetz P et al. Lancet Infect Dis. 2018 Jan.
Use of procalcitonin-guided decision-making to shorten antibiotic therapy in suspected neonatal early-onset sepsis: prospective randomized intervention trial
Stocker M er al. Neonatology. 2010.
Procalcitonin measurements for guiding antibiotic treatment in pediatric pneumonia
Esposito S et al Respir Med . 2011 Dec.
Procalcitonin Guidance to Reduce Antibiotic Treatment of Lower Respiratory Tract Infection in Children and Adolescents (ProPAED): A Randomized Controlled Trial
Bear G et a PLoS One . 2013 Aug .
Duration of Antimicrobial Therapy in Treating Complicated Intra-Abdominal Infections: A Comprehensive Review
Sartelli M et al Surg Infect (Larchmt) . 2016 Feb.
Procalcitonin-guided therapy may reduce length of antibiotic treatment in intensive care unit patients with secondary peritonitis: A multicenter retrospective study
Maseda E et al. J Crit Care . 2015 Jun.
Sample Protocols for Procalcitonin for Adult Sepsis & Adult Lower Respiratory Tract Infections
Sample text to help write clinical protocols when implementing PCT.
Click here
EAPS Webinar: Preserve the power of antibiotics for future generations Targeted antibiotic stewardship with B·R·A·H·M·S PCT
How do Procalcitonin‐aided protocols decrease the antibiotic use in paediatric patient populations, by Dr. Elisabeth Esteban Torné, Hospital San Joan de Déu, Barcelona, Spain.
Click here
Global Antibiotic Stewardship Forum -Antibiotic Stewardship with B·R·A·H·M·S PCT - Learn from experts from around the world
Hear from Prof. Carlo Tascini, MD, Prof. Anucha Apisarnthanarak and Michael R. Broyles.
Click here
ISICEM symposium: Implementation of PCT-aided ABS protocols From real-life integration to long-term benefits and MDRO reduction
Hear from Prof. Evangelos J. Giamarellos-Bourboulis and Prof. Andrea Kwa Lay Hoon.
Click here
COVID 19 Forum: How to overcome antibiotic overuse in COVID-19 patients?
Valerie Vaughn and Neil Powell.
Click here
IFCC symposium: How to overcome antibiotic overuse in COVID-19 patients? Antibiotic stewardship programs with B·R·A·H·M·S PCT
Sean Neath, MD, Ph.D.
Click here
Testimonial: The role of procalcitonin in differential diagnosis of patients with the new corona virus
Prof. Shi Yi, Director of the Dept of Respiratory Intensive Care Unit, JinLing Hospital affiliated with NanJing University Medical College; Chief Physician, Doctoral Supervisor and Postdoctoral Superv
Click here
Testimonial: Covid 19 diagnosis and treatment in China
Prof. Li Shengqing, Director of Respiratory Dept Huashan Hospital affiliated to Fudan University
Click here
Testimonial: The clinical value of procalcitonin in the diagnosis and treatment of new coronary pneumonia
Hou Gang, Deputy Head of LiaNing National Emergency Medical Rescue Team assisting with the outbrreak in Wuham
Click here
Testimonial: Measuring procalcitonin in Covid 19 patients
Hear from Prof. Pierre Hausfater, Head of Emergency Department, Paris France
Click here
Procalcitonin-aided Antibiotic Stewardship: The new paradigm
Michael R. Broyles, PharmD.
Click here
Heart Failure vs. Bacterial Pneumonia
PCT provides insight into the likelihood of systemic bacteria
Overcoming Challenges in COVID-19 Patient Management with PCT
Using procalcitonin to identify bacterial coinfections in COVID-19 patients.
Click here
COVID-19 Positive, Rule-out Bacterial Pneumonia
Learn how procalcitonin was used to assess for bacterial co-infection in a COVID-19+ patient in this case study.
PCT Perspectives: The emergency department
Learn how PCT can help assess presence or absence of a bacterial infection in the emergency department.
Click here
PCT Perspectives: The pharmacy
Learn how PCT can be used to help customize antibiotic therapy for patients with bacterial infections.
Click here
Procalcitonin-guided Antibiotic Therapy Reduces Antibiotic Use for LRTIs in a US Medical Center
Open Forum Infectious Diseases, December 2018.
PCT Perspectives: Introduction to PCT
Using procalcitonin to help with the challenges in diagnosing and treating systemic bacterial infections.
Click here
Treatment of Community-acquired Pneumonia During the COVID-19 Pandemic
Annals of Internal Medicine, August 2020.
Procalcitonin for Antibiotic Stewardship
Learn how to use PCT to help the fight against antibiotic resistance.
Click here
SAPS: Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: A randomised, controlled, open-label trial
The Lancet Infectious Disease, July 2016.
Understanding the Kinetics of Procalcitonin
Discover the unique kinetics of PCT in the host response from bacterial infection.
Click here
Procalcitonin in Current Practice: Linking clinical & financial outcomes
Michael R. Broyles, PharmD and Eric H. Gluck, MD.
Click here
Procalcitonin: Diagnostic aid for appropriate antibiotic decisions
Trevor Van Schooneveld, MD, FACP.
Click here
Implementation Guide
A roadmap for implementing PCT in your hospital, including team building, defining objectives, creating order sets, education and more.
Click here
Use of Procalcitonin (PCT) in Patients Presenting with Overlapping Symptoms
Michael R. Broyles, PharmD, Eric H. Gluck MD. and, Gregory B. Seymann MD, SFHM.
Click here
The Cost Impact of PCT-guided Antibiotic Stewardship Versus Usual Care for Hospitalised Patients with Suspected Sepsis or LRTIs in the US: A health economic model analysis
PloS One, April 2019.
Procalcitonin Pocket Guide
Download the on-the-go guide with PCT algorithms for antibiotic guidance & PCT reference ranges for diagnosis of Systemic Bacterial Infection/Sepsis.
Click here
Procalcitonin as an Aid for Risk Assessment in COVID-19 and Influenza Related Secondary Bacterial Infections
Michael R. Broyles, PharmD.
Click here
Effect of PCT Based Guidelines vs Standard Guidelines on Antibiotic Use in LRTI: ProHOSP randomised control trial
Journal of the American Medical Association, September 2009.
Procalcitonin as a Marker for the Detection of Bacteremia and Sepsis in the Emergency Department
Procalcitonin as a marker for the detection of bacteremia and sepsis in the emergency department
Cost-effectiveness Analysis of a Procalcitonin-guided Decision Algorithm for Antibiotic Stewardship Using Real-world US Hospital Data
OMICS A Journal of Integrative Biology, October 2019.
Use of Procalcitonin for the Diagnosis of Pneumonia in Patients Presenting with a Chief Complaint of Dyspnoea: Results from the BACH trial
European Journal of Heart Failure, March 2012.
Procalcitonin Decrease over 72 Hours in US Critical Care Units Predicts Fatal Outcome in Sepsis Patients
Critial Care, June 2013.
Procalcitonin to Reduce Long-term Infection-associated Adverse Events in Sepsis: A randomized trial (PROGRESS trial)
American Journal of Respiratory and Critical Care Medicine, August 2020.
Serial Procalcitonin Predicts mortality in Severe Sepsis Patients: Results from the MOSES study
Critical Care Medicine, May 2017.
Use of Procalcitonin to Reduce Patients' Exposure to Antibiotics in ICUs (PRORATA Trial): A multicentre randomized controlled trial
The Lancet Infectious Disease, February 2010.
Diagnostic Accuracy of Procalcitonin for Predicting Blood Culture Results in Patients with Suspected Bloodstream Infection: An observational study of 35,343 consecutive patients
Medicine, November 2015.
Antimicrobial use in positive respiratory viral panel: Impact of procalcitonin use and antimicrobial stewardship
Wright State University, 2020.
PCT Perspectives: The critical care perspective
Learn how PCT is used to help assess presence or absence of a bacterial infection in the critical care.
Click here
Impact of Procalcitonin-guided Antibiotic Management on Antibiotic Exposure and Outcomes: Real world evidence
Open Forum Infectious Diseases, October 2019.
Clinical Characteristics of Coronavirus Disease 2019 in China
New England Journal of Medicine, April 2020.
Empiric antibacterial therapy and community-onset bacterial co-infection in patients hospitalized with COVID-19: a multi-hospital cohort study
Clinical Infectious Diseases, August 2020.
Effect of Procalcitonin Testing on Health-care Utilization and Costs in Critically Ill Patients in the US
American College of Chest Physicians, January 2017.
Procalcitonin (PCT) Levels for Ruling-out Bacterial Coinfection in ICU Patients with Influenza: A CHAID decision-tree analysis
Journal of Infection, February 2016.
Differential Diagnosis: Is it bacterial infection or something else?
Learn how procalcitonin was used to aid to differentiate a bacterial infection in this case study.
Procalcitonin as a Marker of Etiology in Adults Hospitalized with Community-acquired Pneumonia
Clinical Infectious Diseases, July 2017.
Chronic Obstructive Pulmonary Disease vs. Heart Failure vs. Bacterial Pneumonia: What is the diagnosis this time?
Differentiating bacterial infection from non-bacterial etiology.
Hemodialysis, Bacterial Pneumonia and Antibiotic De-escalation
Learn how procalcitonin was used for de-escalating antibiotics in a patient on hemodialysis.
Chronic Renal Failure: Rule out peritonitis, peritoneal dialysis
Learn how procalcitonin was used to de-escalate antibiotics in a patient on peritoneal dialysis.
Post-op: PCT decline reflects host response to antibiotics
Learn how procalcitonin reflects the host response in a post-op patient in this case study.
Sepsis: When can I safely stop antibiotics?
Learn how procalcitonin was used to aid antibiotic discontinuation in a patient with a bacterial infection that led to sepsis in this case study.
Procalcitonin: Bacterial Co-infection Risk Assessment in COVID-19
Michael R Broyles, PharmD and Eric H Gluck MD.
Click here
Implementation Checklist
Download this sample checklist to help planning the implementation of procalcitonin in your hospital.
Click here
Procalcitonin in Patients with Severe Coronavirus Disease 2019 (COVID-19): A meta-analysis
International Journal of Clinical Chemistry, June 2020.
Economic evaluation of procalcitonin-guided antibiotic therapy in acute respiratory infections: a US health system perspective
Clinical Chemistry and Laboratory Medicine, March 2015.
Adherence to Procalcitonin Measurement in Inpatient Care: A guide for antibiotic stewardship and high value care
Journal of General Internal Medicine, February 2020.
Serial Procalcitonin as a Predictor of Bacteremia and Need for Intensive Care Unit Care in Adults With Pneumonia, Including Those With Highest Severity: A prospective cohort study
Open Forum Infectious Diseases, January 2017.
PCT Perspectives: Antibiotic stewardship
Learn how to use procalcitonin as an aid to reduce unneeded antibiotic overuse & exposure.
Click here
COVID-19 and Rule out Bacterial Coinfection
Learn how procalcitonin was used to assess for a bacterial co-infection in a patient positive for COVID-19 in this case study.
Lower Respiratory Tract Infection (LRTI): Is it Viral or Bacterial?
Differentiating bacterial from viral infection can be challenging
Procalcitonin (PCT)-Guided Antibiotic Stewardship: An international experts consensus on optimized clinical use
Clinical Chemistry and Laboratory Medicine (CCLM), August 2019.
ON24: PCT Implementation Best Practices
Maureen A Turner, BSN, RN and Kimberly Capan, BSN, RN
Click here
Effective PCT Implementation Strategies Reduce Unnecessary Testing While Improving Outcomes (How to be an Expert!)
Michael R. Broyles, PharmD.
Click Here
Applications of Procalcitonin-aided Decision Making for Antibiotic Stewardship in Emergency Care
Larissa May, MD, MSPH, MSHS
Click Here