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Invitrogen
Human METAP1 (aa 286-359) Control Fragment Recombinant Protein
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Product Details
RP-102796
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
SVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEH
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (100%), Rat (100%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-58202. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Methionine aminopeptidase 1 (METAP1) is a gene located on chromosome 4q24, encoding an enzyme responsible for the removal of N-terminal methionine residues from newly synthesized proteins. METAP1 is essential for protein maturation and function, as the cleavage of methionine allows subsequent modifications that are crucial for protein stability and activity. This enzyme is ubiquitously expressed in various tissues and plays a significant role in post-translational modification processes, affecting cellular homeostasis and protein regulation. METAP1 is involved in several physiological pathways, including cell cycle progression, signal transduction, and stress response. Dysregulation of METAP1 activity can impact protein function and is associated with diseases like cancer, reflecting its importance in cellular proliferation and growth. Research into METAP1 focuses on its potential as a therapeutic target for modulating protein synthesis and its implications in diseases characterized by uncontrolled cell growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp781C0419; EC 3.4.11.18; KIAA0094MAP 1; MAP 1; MAP1; metAP 1; Methionine aminopeptidase 1; Peptidase M; Peptidase M 1
Gene Aliases: KIAA0094; MAP1A; METAP1; MetAP1A
UniProt ID: (Human) P53582
Entrez Gene ID: (Human) 23173
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