Anti-IKK alpha/beta Antibodies

IKK alpha/beta Antibodies

Antibodies that detect IKK alpha/beta can be used in several scientific applications, including Immunohistochemistry, Western Blot, Immunocytochemistry, ELISA and Flow Cytometry. These antibodies target IKK alpha/beta in Human, Mouse, Rat, Non-human primate and Bovine samples. Our IKK alpha/beta polyclonal, recombinant monoclonal, recombinant polyclonal and monoclonal antibodies are developed in Rabbit. These antibodies have been verified by Cell treatment and Knockout to confirm specificity to IKK alpha/beta. Find the IKK alpha/beta antibody that fits your needs. Choose from 1 of 17 IKK alpha/beta antibodies, which have been validated in experiments with 3 publications and 57 images ... View more Antibodies that detect IKK alpha/beta can be used in several scientific applications, including Immunohistochemistry, Western Blot, Immunocytochemistry, ELISA and Flow Cytometry. These antibodies target IKK alpha/beta in Human, Mouse, Rat, Non-human primate and Bovine samples. Our IKK alpha/beta polyclonal, recombinant monoclonal, recombinant polyclonal and monoclonal antibodies are developed in Rabbit. These antibodies have been verified by Cell treatment and Knockout to confirm specificity to IKK alpha/beta. Find the IKK alpha/beta antibody that fits your needs. Choose from 1 of 17 IKK alpha/beta antibodies, which have been validated in experiments with 3 publications and 57 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications.

Target Information

IKK alpha/beta is encoded by CHUK (conserved helix-loop-helix ubiquitous kinase) and IKKB (inhibitor of kappa light polypeptide gene enhancer in B-cells) gene located in chromosome 10 and 8 respectively in humans. Upon stimulation by agents that activate the NF-kB pathway such as TNF alpha, the two subunits of IKK complex, IKK alpha and IKK -beta alongside a regulator NEMO (IKK gamma) phosphorylates IkB proteins. This targets the later for ubiquitin mediated degradation and phosphorylation of NF-kB leading to subsequent translocation to the nucleus. Phosphorylation at serine 176 and 180 located in the activation loop causes a confirmation change that is required for the activation of the kinases.

Synonyms

AI132552; AI256658; AIM-1; CHUK; Chuk1; component of inhibitor of nuclear factor kappa B kinase complex; conserved helix-loop-helix ubiquitous kinase; EC 2.7.11.10; Fbx24; Fbxo24; I kappa B kinase 1; i kappa-B kinase alpha; IkappaB kinase; I-kappa-B kinase 1; I-kappa-B kinase 2; IkappaB kinase alpha; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; I-kappa-B-kinase beta; IkB kinase alpha subunit; IkB kinase-alpha; IkB kinase-beta; ikBKA; Ikbkb; IKK alpha; IKK[b]; IKK1; IKK2; IKK-2; IKKA; IKK-A; IKK-a kinase; IKK-alpha; Ikkb; IKK-B; IKKbeta; IKK-beta; IMD15; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of kappaB kinase beta; inhibitor of nuclear factor kappa B kinase beta subunit; inhibitor of nuclear factor kappa B kinase subunit beta; inhibitor of nuclear factor kappa-B kinase subunit alpha; Inhibitor of nuclear factor kappa-B kinase subunit beta; NFKBIKA; NFKBIKB; Nuclear factor NFkappaB inhibitor kinase alpha; nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NF-kappa-B inhibitor kinase beta; TCF16; TCF-16; TCF17; Transcription factor 16