Antibodies that detect IKK alpha/beta can be used in several scientific applications, including Western Blot, Immunocytochemistry, Immunohistochemistry (Paraffin), ELISA and Immunohistochemistry (Frozen). These antibodies target IKK alpha/beta in Human, Mouse, Rat, Non-human primate and Bovine samples. Our IKK alpha/beta polyclonal, recombinant monoclonal, recombinant polyclonal and monoclonal antibodies are developed in Rabbit. These antibodies have been verified by Cell treatment and Knockout to confirm specificity to IKK alpha/beta. Find the IKK alpha/beta antibody that fits your needs. Choose from 1 of 17 IKK alpha/beta antibodies, which have been validated in experiments with 2 publications and 58 images featured in our data gallery.
Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications.
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IKK alpha/beta is encoded by CHUK (conserved helix-loop-helix ubiquitous kinase) and IKKB (inhibitor of kappa light polypeptide gene enhancer in B-cells) gene located in chromosome 10 and 8 respectively in humans. Upon stimulation by agents that activate the NF-kB pathway such as TNF alpha, the two subunits of IKK complex, IKK alpha and IKK -beta alongside a regulator NEMO (IKK gamma) phosphorylates IkB proteins. This targets the later for ubiquitin mediated degradation and phosphorylation of NF-kB leading to subsequent translocation to the nucleus. Phosphorylation at serine 176 and 180 located in the activation loop causes a confirmation change that is required for the activation of the kinases.
Conserved helix-loop-helix ubiquitous kinase; EC 2.7.11.10; I-kappa-B kinase 1; I-kappa-B kinase 2; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; I-kappa-B-kinase beta; IkappaB kinase; IkB kinase alpha subunit; IKK-a kinase; IKK-B; IKK1; IKK2; Inhibitor of nuclear factor kappa-B kinase subunit alpha; Inhibitor of nuclear factor kappa-B kinase subunit beta; NFKBIKA; NFKBIKB; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NF-kappa-B inhibitor kinase beta; Nuclear factor NFkappaB inhibitor kinase alpha; Serine/threonine protein kinase IKBKB; TCF-16; TCF17; Transcription factor 16
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