The complement system is a crucial component of our innate immune system that supports the body's defense against injuries and infections. Its functions include activation of the inflammatory response, phagocytosis-mediated destruction of bacteria and viruses, pathogen agglutination, and cell lysis of susceptible organisms.
There are three distinct pathways through which the complement cascade can be activated, each triggered by different mechanisms. These pathways involve more than 50 different proteins.
Complement testing is recommended for the assessment of specific complement disorders.1
Range of assays
CE marked & 510k cleared
Primary immunodeficiency screening
E. de Vries2 in collaboration with European Society for Immunodeficiencies (ESID) members developed a protocol to screen for primary immunodeficiency
|Human complement functional assay – CH50
|Human complement protein assay - C1 inactivator
|This functional assay aids in the characterization of classical complement pathway activity, and therefore aids in the investigation for complement deficiencies. This assay may be used where there is a clinical suspicion of immunological disorders.
|This assay quantifies the levels of C1i and can therefore aid in the characterization of complement deficiencies. The assays are also cleared as an aid in the diagnosis of hereditary angioedema.
|Human complement protein assay - C3
|Human complement protein assay - C4
|This assay quantifies the levels of C3 and can therefore aid in the characterization of complement deficiencies. This assay could be used if there is a suspicion of immunodeficiencies or as further testing dependent on initial tests.
|This assay quantifies the levels of C4 and can therefore aid in the characterization of complement deficiencies. Inherited or acquired deficiencies in C1 inhibitor cause decreased serum levels of C4, which are associated with angioedemas.
|*The ranges provided in the image have been obtained from a limited number of samples and are intended for guidance purposes only. Expected values may vary with age, sex, sample type, diet and geographical location. Each laboratory should verify the transferability of the expected values to its own population and, if necessary, determine its own reference interval.
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