Non-HLA Antibodies: Preliminary Experience 2021 International Clinical Webinar
Dr. Koefoed-Nielsen presents data for a patient who had undergone two kidney transplantations, experienced allograft failure soon after receiving a third kidney transplant. With a negative crossmatch and no DSA detected, further investigation was required. Non-HLA autoantibodies can be associated with adverse transplantation outcomes1, so they screened the patient and eight others who experienced similar outcomes for autoantibodies using the One Lambda™ LABScreen™ Autoantibody Group 1 and Group 2 assays. All nine patients had high levels of REG3A, LMNB, PRKCH, GAPDH, HNRNPK, VM, and IFNG autoantibodies, which has been correlated with humoral rejection in kidney and heart transplant recipients.
Speaker:
Pernille Koefoed-Nielsen, MD, PhD
Tissue Typing Laboratory,
Department of Clinical Immunology
Aarhus Universitet Hospital, Denmark
Recorded:
Nov 24, 2021
Videos In This Series
- New Antibody Advances ❯
- The Potential of Imlifidase ❯
- Advancements in AllType FASTPlex ❯
- An Introduction to and the Evolution of the UK Living Kidney Sharing Scheme ❯
- HLA Typing by Next-Generation Sequencing (NGS) Using the AllType Fastplex Kit and the Relevance of Anti-HLA Antibody Monitoring After Kidney Transplantation ❯
- Non-HLA Antibodies: Preliminary Experience ❯
- Cardinal, H. et al. JASN February 2017, 28 (2) 400-406. https://doi.org/10.1681/ASN.2016070756
