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Citations & References (106)
Invitrogen™
Nonyl Acridine Orange (Acridine Orange 10-Nonyl Bromide)
Nonyl acridine orange is well retained in the mitochondria making it a useful probe for following mitochondria during isolation andRead more
| Catalog Number | Quantity |
|---|---|
| A1372 | 100 mg |
Catalog number A1372
Price (KRW)
210,000
Online offer
Ends: 31-Dec-2025
247,000Save 37,000 (15%)
Each
Quantity:
100 mg
Price (KRW)
210,000
Online offer
Ends: 31-Dec-2025
247,000Save 37,000 (15%)
Each
Nonyl acridine orange is well retained in the mitochondria making it a useful probe for following mitochondria during isolation and after cell fusion. The mitochondrial uptake is reported to not to depend on membrane potential, unlike many other mitochondrial probes. It is toxic at high concentrations and apparently binds to cardiolipin in all mitochondria, regardless of their energetic state. This derivative has been used to analyze mitochondria by flow cytometry, to characterize multidrug resistance and to measure changes in mitochondrial mass during apoptosis.
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For Research Use Only. Not for use in diagnostic procedures.
Specifications
ColorOrange
Detection MethodFluorescence
For Use With (Equipment)Fluorescence Microscope
Quantity100 mg
Shipping ConditionRoom Temperature
Label TypeFluorescent Dye
Product TypeMitochondria Probe
SubCellular LocalizationMitochondria
Unit SizeEach
Contents & Storage
Store at room temperature and protect from light.
Citations & References (106)
Citations & References
Abstract
Analysis of mitochondria isolated from single cells.
Journal:Analytical and bioanalytical chemistry
PubMed ID:16937092
Human epidermal cells progressively lose their cardiolipins during ageing without change in mitochondrial transmembrane potential.
Journal:Mech Ageing Dev
PubMed ID:7745994
Mitochondria dysfunction is considered to be a major cause of the modifications that occur during cell ageing. For this reason, cardiolipin, a suitable marker of the chondriome, as well as the mitochondrial transmembrane potential were examined in keratinocytes obtained from 9- to 75-year-old women. The study was carried out by
Tamoxifen but not 4-hydroxytamoxifen initiates apoptosis in p53(-) normal human mammary epithelial cells by inducing mitochondrial depolarization.
Journal:J Biol Chem
PubMed ID:11094056
'Despite the widespread clinical use of tamoxifen as a breast cancer prevention agent, the molecular mechanism of tamoxifen chemoprevention is poorly understood. Abnormal expression of p53 is felt to be an early event in mammary carcinogenesis. We developed an in vitro model of early breast cancer prevention to investigate how
Sortase A localizes to distinct foci on the Streptococcus pyogenes membrane.
Journal:Proc Natl Acad Sci U S A
PubMed ID:19017791
'Cell wall peptidoglycan-anchored surface proteins are essential virulence factors in many gram-positive bacteria. The attachment of these proteins to the peptidoglycan is achieved through a transpeptidation reaction, whereby sortase cleaves a conserved C-terminal LPXTG motif and covalently attaches the protein to the peptidoglycan precursor lipid II. It is unclear how
Methods for assessing autophagy and autophagic cell death.
Journal:Methods Mol Biol
PubMed ID:18425442
'Autophagic (or type 2) cell death is characterized by the massive accumulation of autophagic vacuoles (autophagosomes) in the cytoplasm of cells that lack signs of apoptosis (type 1 cell death). Here we detail and critically assess a series of methods to promote and inhibit autophagy via pharmacological and genetic manipulations.