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Citations & References (2)
Thermo Scientific™
DMP (dimethyl pimelimidate)
Thermo Scientific Pierce DMP is dimethyl pimelimidate, a membrane-permeable crosslinker that contains an amine-reactive imidoester group at each end ofRead more
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| Catalog Number | Quantity |
|---|---|
| 21666 | 50 mg |
| 21667 | 1 g |
Catalog number 21666
Price (JPY)Contact Us ›
12,800
Each
Quantity:
50 mg
Thermo Scientific Pierce DMP is dimethyl pimelimidate, a membrane-permeable crosslinker that contains an amine-reactive imidoester group at each end of a 7-atom spacer arm.
Features of dimethyl pimelimidate:
• Reactive groups: imidoester (both ends)
• Reactive towards: amino groups (primary amines)
• Mid-length reagent of three similar imidoester crosslinkers, which include DMA, DMP and DMS
• Water-soluble
• Imidoesters react with amines at alkaline pH values (pH 8-10) to form amidine bond
• Amidine bond retains net charge character of protein primary amine to which it reacts
• Reversible at high pH values
• Tool for study of quarternary structure of proteins
Product References
Crosslinker Application Guide -- search for recent literature references for this product
Related Products
DMA (dimethyl adipimidate)
DMS (dimethyl suberimidate)
DTBP (Wang and Richard's Reagent)
Features of dimethyl pimelimidate:
• Reactive groups: imidoester (both ends)
• Reactive towards: amino groups (primary amines)
• Mid-length reagent of three similar imidoester crosslinkers, which include DMA, DMP and DMS
• Water-soluble
• Imidoesters react with amines at alkaline pH values (pH 8-10) to form amidine bond
• Amidine bond retains net charge character of protein primary amine to which it reacts
• Reversible at high pH values
• Tool for study of quarternary structure of proteins
Product References
Crosslinker Application Guide -- search for recent literature references for this product
Related Products
DMA (dimethyl adipimidate)
DMS (dimethyl suberimidate)
DTBP (Wang and Richard's Reagent)
For Research Use Only. Not for use in diagnostic procedures.
Specifications
Cell PermeabilityYes
DescriptionDMP
FormPowder
Labeling MethodChemical Labeling
Molecular Weight (g/mol)259.17
PEGylatedNo
Product LinePierce
Quantity50 mg
Reactive MoietyImidoester
Shipping ConditionAmbient
SolubilityWater
Spacer Arm Length9.2 Å
Water SolubleYes
Chemical ReactivityAmine-Amine
CleavableNo
Crosslinker TypeHomobifunctional
FormatStandard
Product TypeCrosslinker
SpacerShort (<10 Å)
Unit SizeEach
Contents & Storage
Upon receipt store desiccated at 4°C.
Citations & References (2)
Citations & References
Abstract
Discovery of lung cancer biomarkers by profiling the plasma proteome with monoclonal antibody libraries.
Journal:Mol Cell Proteomics
PubMed ID:21947365
'A challenge in the treatment of lung cancer is the lack of early diagnostics. Here, we describe the application of monoclonal antibody proteomics for discovery of a panel of biomarkers for early detection (stage I) of non-small cell lung cancer (NSCLC). We produced large monoclonal antibody libraries directed against the
Cellular and subcellular distribution of the type-2 vasopressin receptor in the kidney.
Journal:Am J Physiol Renal Physiol
PubMed ID:17553938
Arginine vasopressin (AVP) is essential for maintaining body fluid homeostasis. The antidiuretic effects of AVP are initialized by binding of AVP to the type-2 vasopressin receptor (V2R) in the kidney collecting duct (CD), resulting in the exocytic insertion of aquaporin-2 (AQP-2) water channels into the apical plasma membrane. In this