Thermo Scientific™

DMS (dimethyl suberimidate)

Catalog number:  20700

 Related applications:

Protein Labeling & Crosslinking

Error loading your content!

  Catalog number
Select a plan
Unit size
Price ({{currency}}) Availability Qty
{{product.sku}} {{product.sku}} also known as {{product.formattedSku}} 
Pro add-ons

Your on-site stock

›› {{supplyCenter.scName}}({{scProduct.stockOnHand}} In stock)
›› {{supplyCenter.scName}}(Out of stock)
›› {{supplyCenter.scName}}
This item is not currently available on-site. Depending on your Supply Center settings you may be able to add the item to cart above else use the Order Non-Stocked Items' tab on the Supply Center home page.
Back to top


Thermo Scientific Pierce DMS is dimethyl suberimidate, a membrane-permeable crosslinker that contains an amine-reactive imidoester group at each end of an 8-atom spacer arm.

Features of dimethyl suberimidate:

Reactive groups: imidoester (both ends)
Reactive towards: amino groups (primary amines)
• Longest of three similar imidoester crosslinkers, which include DMA, DMP and DMS
• Water-soluble
• Imidoesters react with amines at alkaline pH values (pH 8-10) to form amidine bond
• Amidine bond retains net charge character of protein primary amine to which it reacts
• Reversible at high pH values
• Tool for study of quarternary structure of proteins

Product References
Crosslinker Application Guide -- search for recent literature references for this product

Related Products
DMA (dimethyl adipimidate)
DMP (dimethyl pimelimidate)
DTBP (Wang and Richard's Reagent)
For Research Use Only. Not for use in diagnostic procedures.


Crosslinker Type: Homobifunctional
Labeling Method: Chemical Labeling
Product Line: Pierce™
Product Size: 1 g
Solubility: Water
Spacer: Mid-Length

Contents & storage

Store desiccated at 4°C. Shipped at ambient temperature.


Manuals & protocols