Zitierungen und Referenzen (5)

Thermo Scientific™

DMS (dimethyl suberimidate)

Thermo Scientific Pierce DMS ist Dimethylsuberimidat, ein membrangängiger Crosslinker, der an jedem Ende eines Spacerarms aus 8 Atomen eine aminreaktiveWeitere Informationen

Katalognummer	Menge
20700	1 g

Katalognummer 20700

Preis (EUR)

209,00

Menge:

Großbestellung oder individuelle Größe anfordern

Preis (EUR)

209,00

Thermo Scientific Pierce DMS ist Dimethylsuberimidat, ein membrangängiger Crosslinker, der an jedem Ende eines Spacerarms aus 8 Atomen eine aminreaktive Imidoester-Gruppe enthält.

Merkmale von Dimethylsuberimidat:

• Reaktive Gruppen: Imidoester (beide Enden)
• Reaktiv gegen: Aminogruppen (primäre Amine)
• Längste von drei ähnlichen Imidoester Crosslinkern, zu denen DMA, DMP und DMS gehören
•Wasserlöslich
• Imidoester reagieren mit Aminen bei alkalischen pH-Werten (pH 8 bis 10) und bilden Amidin-Bindung
• Amidin-Bindungen bleibt der Netzladecharakter des Protein-Primäramin erhalten, auf das er reagiert
• Reversibel bei hohen pH-Werten
• Instrument für die Untersuchung der quartären Struktur von Proteinen

Produktreferenzen
Crosslinker Anwendungsleitfaden -- Suchen Sie nach aktuellen Literaturreferenzen für dieses Produkt

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Nur für Forschungszwecke. Nicht zur Verwendung bei diagnostischen Verfahren.

Specifications

ZellpermeabilitätJa

BeschreibungDMS

FormPulver

MarkierungsmethodeChemische Markierung

Molekulargewicht273,2

PEGyliertNein

ProduktliniePierce

Menge1 g

Reaktiver TeilImidoester

VersandbedingungUmgebungstemperatur

LöslichkeitWasser

Länge des Spacer-Arms11,0 Å

WasserlöslichJa

Chemische ReaktivitätAmin-zu-Amin

CleavableNein

Crosslinker-TypHomobifunktional

FormatStandard

ProdukttypCrosslinker

AbstandshalterMittel (10 bis 30 Å)

Unit SizeEach

Inhalt und Lagerung

Nach Erhalt getrocknet bei 4 °C lagern.

Häufig gestellte Fragen (FAQ)

Can you provide the shelf-life for DMS (dimethyl suberimidate)?

DMS (dimethyl suberimidate) is covered under our general 1-year warranty and is guaranteed to be fully functional for 12 months from the date of shipment, if stored as recommended. Please see section 8.1 of our Terms & Conditions of Sale (https://www.thermofisher.com/content/dam/LifeTech/Documents/PDFs/Terms-and-Conditions-of-Sale.pdf) for more details.

Find additional tips, troubleshooting help, and resources within our Protein Purification and Isolation Support Center.

Zitierungen und Referenzen (5)

Zitierungen und Referenzen

Abstract

Discovery of lung cancer biomarkers by profiling the plasma proteome with monoclonal antibody libraries.

Authors:Guergova-Kuras M, Kurucz I, Hempel W, Tardieu N, Kádas J, Malderez-Bloes C, Jullien A, Kieffer Y, Hincapie M, Guttman A, Csánky E, Dezso B, Karger BL, Takács L

Journal:Mol Cell Proteomics

PubMed ID:21947365

'A challenge in the treatment of lung cancer is the lack of early diagnostics. Here, we describe the application of monoclonal antibody proteomics for discovery of a panel of biomarkers for early detection (stage I) of non-small cell lung cancer (NSCLC). We produced large monoclonal antibody libraries directed against the ... More

The structural characterization of a prophage-encoded extracellular DNase from Streptococcus pyogenes.

Authors:Korczynska JE, Turkenburg JP, Taylor EJ

Journal:Nucleic Acids Res

PubMed ID:21948797

'The pathogenic bacterium Group A Streptococcus pyogenes produces several extracellular DNases that have been shown to facilitate invasive infection by evading the human host immune system. DNases degrade the chromatin in neutrophil extracellular traps, enabling the bacterium to evade neutrophil capture. Spd1 is a type I, nonspecific ßßa/metal-dependent nuclease from ... More

Outer membrane lipoprotein Lpp is Gram-negative bacterial cell surface receptor for cationic antimicrobial peptides.

Authors:Chang TW, Lin YM, Wang CF, Liao YD

Journal:J Biol Chem

PubMed ID:22084237

Antimicrobial peptides/proteins (AMPs) are important components of the host innate defense mechanisms. Here we demonstrate that the outer membrane lipoprotein, Lpp, of Enterobacteriaceae interacts with and promotes susceptibility to the bactericidal activities of AMPs. The oligomeric Lpp was specifically recognized by several cationic a-helical AMPs, including SMAP-29, CAP-18, and LL-37; ... More

Inhibition of RNase L and RNA-dependent protein kinase (PKR) by sunitinib impairs antiviral innate immunity.

Authors:Jha BK, Polyakova I, Kessler P, Dong B, Dickerman B, Sen GC, Silverman RH

Journal:J Biol Chem

PubMed ID:21636578

RNase L and RNA-dependent protein kinase (PKR) are effectors of the interferon antiviral response that share homology in their pseudokinase and protein kinase domains, respectively. Sunitinib is an orally available, ATP-competitive inhibitor of VEGF and PDGF receptors used clinically to suppress angiogenesis and tumor growth. Sunitinib also impacts IRE1, an ... More

Human mitochondrial DNA helicase TWINKLE is both an unwinding and annealing helicase.

Authors:Sen D, Nandakumar D, Tang GQ, Patel SS

Journal:J Biol Chem

PubMed ID:22383523

TWINKLE is a nucleus-encoded human mitochondrial (mt)DNA helicase. Point mutations in TWINKLE are associated with heritable neuromuscular diseases characterized by deletions in the mtDNA. To understand the biochemical basis of these diseases, it is important to define the roles of TWINKLE in mtDNA metabolism by studying its enzymatic activities. To ... More