f311 Megrim

f311 Megrim Scientific Information

Type:

Whole Allergen

Display Name:

Megrim

Allergen code:

f311

Family:

Bothidae

Latin Name:

Lepidorhombus whiffiagonis

WHO/ICD-11 code:

XM95M8

(ICD-11 is currently under implementation by WHO and the ICD-11 codes displayed in the encyclopedia may not yet be available in all countries)

Clinical Relevance

Megrim, also called e.g. white sole or whiff, belongs to the order Pleuronectiformes and is one of the most frequently consumed fish in Spain.

In a study in children, the clinical symptoms induced by this fish allergy were urticaria and angioedema (92.4%) in 79 patients, followed by atopic dermatitis (17.7%) and inhalation-related asthma (13.9%) (1). In an immunoblot study of specific IgE binding, Megrim bound the greatest amount compared with the related sole and witch (1).

IgE-mediated reactions

The most common symptoms in a group of megrim-allergic children were urticaria and angioedema.
Asthma related to inhalation of cooking steam was reported.

Molecular Aspects

Cross-reactivity

Species within groups of fish, like Gadiformes (examples: codfish and hake) and Scombroid fishes (examples: mackerel and tuna) seem to share allergenic components. The overlap of allergen specificity between the groups seems to be moderate or even small

Compiled By

Last Reviewed- April 2022

References

Pascual, C; Martín Esteban, M; Fernández Crespo, J. Fish allergy: Evaluation of the importance of cross-reactivity. J Pediatr; 1992; 121: S29-34.