The Binding Site provides your laboratory with the tests for all the laboratory’s immunoglobulin (Ig) subclass testing needs and is the only supplier of an automated turbidimetric method for IgA 1-2.
There are four different IgG subclasses. The most obvious differences between the subclasses can be seen in the hinge regions, where for instance IgG1 has a short hinge region and IgG3 has a longer hinge region.
These differences add up to partially explain why the individual subclass have slightly different functions and properties. IgG1 and IgG3 are strong mediators of both FcγR and complement-mediated functions, and are the predominant subclasses involved in the response to protein antigens. IgG2 is a weak mediator of FcγR and complement-mediated functions and is involved in the response to polysaccharide antigens. IgG4 has a minimal ability to activate effector cells or fix complement.
The reference material reflects the true biological distribution of the IgG1,2 (IgG1>IgG2>IgG3>IgG4)
Ig subclass assays aid in the characterization of many immunodeficiency diseases including hypogammaglobulinaemia, hypergammaglobulinaemia.
Together with other tests, it provides a holistic view of the patient’s immune status
What is this test?
*There is currently no consensus on what calibration material to use for measuring IgG subclasses. The Binding Site used CRM 470, which has now been replaced by ERM-DA470k due to stock depletion. The calibration used in The Binding Site IgG subclasses assays is internationally recognized and accepted by the International Federation of Clinical Chemists (IFCC), as it reflects the subclass biological distribution (IgG1>IgG2>IgG3>IgG4)
IgA subclasses Introduction
There are two different IgA subclasses. IgA is responsible for mucosal immunity and is therefore the first line of defence for the majority of infections. Normal serum concentrations of both IgA subclasses may be very low therefore a sensitive, reproducible assay is essential.
IgA subclass testing allows the laboratory to detect global changes in the production or stability of the IgA subclasses. Obtaining these results, together with other test results, allows for a more complete picture of the patient’s condition, and more detailed overall clinical picture.
The Binding Site provides your lab with the tests for all the laboratory's immunoglobulin subclass testing needs, with the only automated turbidimentric method for IgA 1-2.
Our automated and optimized IgA Subclass assays provide: