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Choose the system configuration that meets your throughput, turnaround time, and budget needs.
Choose your system
| Ion GeneStudio S5 System | Ion GeneStudio S5 Plus System | Ion GeneStudio S5 Prime System | |
| Max. throughput/day (chip type) | 15 Gb | 50 Gb | 50 Gb |
| (one Ion 540 Chip) | (one Ion 560 chip) | (one Ion 560 chip) | |
| Total sequencing and analysis time at max. throughput | 19 hr (Ion 540 Chip) | 16 hr (Ion 560 Chip) | 8.5 hr (Ion 550, 560 chips) |
| Compatible chips | Ion 510, 520, 530, 540 chips | Ion 510, 520, 530, 540, 550 and 560 chips | |
Detailed system specs
Flexibility in throughput and workflow for a broad range of NGS applications
| Chip type | Number of reads | Read length (output1) | Ion GeneStudio S5 System | Ion GeneStudio S5 Plus System | Ion GeneStudio S5 Prime System |
| Turnaround time2 (sequencing run plus analysis time) | |||||
| Ion 510™ Chip | 2-3 million | 200 bp (0.3-0.5 Gb) | 4.5 hours | 3 hours | 3 hours |
| 400 bp (0.6-1 Gb) | 10.5 hours | 5 hours | 5 hours | ||
| Ion 520™ Chip | 4-6 million | 200 bp (0.6-1 Gb) | 7.5 hours | 3.5 hours | 3 hours |
| 400 bp (1.2-2 Gb) | 12 hours | 5.5 hours | 5.5 hours | ||
| 3-4 million | 600 bp (0.5-1.5 Gb) | 12 hours | 5.5 hours | 5.5 hours | |
| Ion 530™ Chip | 15-20 million | 200 bp (3-4 Gb) |
10.5 hours | 5 hours | 4 hours |
| 400 bp (6-8 Gb) |
21.5 hours | 8 hours | 6.5 hours | ||
| 9-12 million | 600 bp (1.5-4.5 Gb) | 21 hours | 8 hours | 7 hours | |
| Ion 540™ Chip | 60-80 million | 200 bp (10-15 Gb) | 19 hours | 10 hours | 6.5 hours |
| Ion 550™ Chip | 100-130 million | 200 bp (20-25 Gb) | - | 11.5 hours | 8.5 hours |
| Ion 560™ Chip3,4 | 240-280 million | 200 bp (45-50 Gb) | - | 16 hours | 8.5 hours |
1 Output is dependent on read length and application.
2 Instrument run time is based on the latest Prime T560 server data.
3 The Ion 560™ Chip is not compatible with the Ion S5™ XL Sequencer
4 The Ion 560™ Chip requires Torrent Suite™ Software version 5.22 or later.
Featured Ion GeneStudio S5 systems applications
Popular applications and panels |
Panel description |
Supported chips and sample throughput* |
| Oncology research | ||
| Oncomine Comprehensive Assay Plus | Comprehensive genomic profiling of 517 genes plus genomic signatures | Ion 540 Chip (2 samples/run) Ion 550 Chip (4 samples/run) Ion 560 Chip (7-10 samples/run) |
| Oncomine Comprehensive Assay v3 | Enable biomarker discovery of SNVs and indels and full gene sequencing from 161 genes | Ion 540 Chip (8 samples/run) Ion 550 Chip (16 samples/run) |
| Oncomine Myeloid Research Assay | Genomic profiling of myeloid malignancy samples | Ion 520 Chip (4 samples/run) Ion 530 Chip (8-12 samples/run) |
| Oncomine Focus Assay | Identify solid tumor-relevant SNVs, indels, CNVs, and gene fusions from 52 genes | Ion 510 Chip (4 samples/run) Ion 520 Chip (8 samples/run) Ion 530 Chip (26 samples/run) |
| Ion AmpliSeq Cancer Hotspot Panel v2 | Identify cancer hotspot SNVs from 10 ng of FFPE derived DNA | Ion 510 Chip (4 samples/run) Ion 520 Chip (8 samples/run) Ion 530 Chip (26 samples/run) |
| Oncomine Lung cfDNA Assay | Detect rare somatic mutations in genes relevant to non-small cell lung cancer | Ion 530 Chip (8 samples/run) Ion 540 Chip (32 samples/run) Ion 550 Chip (60-64 samples/run) |
| Oncomine Pan-Cancer Cell-Free Assay | Detect rare somatic mutations in genes across multiple cancer types | Ion 530 Chip (1 sample/run) Ion 540 Chip (4 samples/run) Ion 550 Chip (7-8 samples/run) |
| Oncomine Immune Response Research Assay | Interrogate genes involved in immune response pathways | Ion 520 Chip (4 samples/run) Ion 530 Chip (8 samples/run) |
| Gene expression | ||
| Ion AmpliSeq Transcriptome Human Gene Expression Kit | Research global gene expression levels | Ion 530 Chip (2 samples/run) Ion 540 Chip (8 samples/run) Ion 550 Chip (16 samples/run) Ion 560 Chip (32 samples/run) |
| Ion AmpliSeq Transcriptome Mouse Gene Expression Kit | Research global gene expression levels | Ion 530 Chip (2 samples/run) Ion 540 Chip (8 samples/run) Ion 550 Chip (16 samples/run) |
| Inherited disease research | ||
| Ion AmpliSeq Exome RDY Panel | Discover rare mutations of the whole exome | Ion 540 Chip (2 samples/run) Ion 550 Chip (4 samples/run) |
| Ion AmpliSeq Pharmacogenomics Research Panel (40 genes) | Investigate known variants associated with drug metabolism | Ion 510 Chip (48 samples/run) Ion 520 Chip (96 samples/run) Ion 530 Chip (384 samples/run) Ion 540 Chip (384 samples/run) |
| Ion AmpliSeq On-Demand Panel | Identify variants in genes associated with inherited disease | Ion 510-Ion 550 Chip (Up to 384/run) varies by number of genes in panel |
| Reproductive health research | ||
| Ion ReproSeq PGS Kits | Identify aneuploidy in DNA from embryo samples | Ion 510 Chip (16 samples/run) Ion 520 Chip (24 samples/run) Ion 530 Chip (96 samples/run) |
| Infectious disease research | ||
| Ion AmpliSeq TB Research Panel (order at ampliseq.com) | Identify variants associated with antimicrobial resistance in Mycobacterium tuberculosis (TB) | Ion 510 Chip (48 samples/run) Ion 520 Chip (84 samples/run) Ion 530 Chip (272 samples/run) Ion 540 Chip (384 samples/run) |
| Ion AmpliSeq Ebola Research Panel (order at ampliseq.com) | Identify the presence of Ebola virus | Ion 510 Chip (48 samples/run) Ion 520 Chip (84 samples/run) Ion 530 Chip (272 samples/run) Ion 540 Chip (384 samples/run) |
| Ion 16S Metagenomics Kit | Identify bacterial species in mixed samples | Ion 510 Chip (24 samples/run) Ion 520 Chip (48 samples/run) Ion 530 Chip (192 samples/run) |
*The number of samples per run/chip serves as a guide, and the actual number of samples loaded will depend on your needs for number of reads and depth of coverage. It is important to note that as the number of libraries per chip increases, it becomes more difficult to balance the reads between libraries. In addition, libraries from FFPE tissue tend to produce more variable results. We suggest combining fewer libraries initially and determining real limits empirically.
For Research Use Only. Not for use in diagnostic procedures.
PMR-005955