Hexamethyldisilazane, Electronic grade, 99+%

Name: Hexamethyldisilazane, Electronic grade, 99+%
SKU: 042039.22

CAS: 999-97-3 | C6H19NSi2 | 161.395 g/mol

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数量:

25 mL

100 g

100 mL

500 mL

500 g

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製品番号（カタログ番号） 042039.22

または、製品番号042039-22

価格（JPY）

数量:

100 g

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化学物質識別子

CAS999-97-3

IUPAC Namebis(trimethylsilyl)amine

Molecular FormulaC6H19NSi2

InChI KeyFFUAGWLWBBFQJT-UHFFFAOYSA-N

SMILESC[Si](C)(C)N[Si](C)(C)C

さらに表示

仕様

スペックシート

Total Metal Impurities≤1 ppm

Turbidity≤1.0 NTU

Impurity contentChlorides: ≤1.0 ppm

Appearance (Color)Clear cololress

Infrared spectrumConforms

さらに表示

Hexamethyldisilazane is used as a solvent in organic synthesis and organometallic chemistry. It is often used as an adhesion promoter for photoresist in photolithography. Further, it is used for the preparation of trimethylsilyl ethers from hydroxy compounds. It is used as an alternative to critical point drying during sample preparation in electron microscopy. It is added to analyte to get silylated diagnostic products during pyrolysis in gas chromatography- mass spectrometry.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Hexamethyldisilazane is used as a solvent in organic synthesis and organometallic chemistry. It is often used as an adhesion promoter for photoresist in photolithography. Further, it is used for the preparation of trimethylsilyl ethers from hydroxy compounds. It is used as an alternative to critical point drying during sample preparation in electron microscopy. It is added to analyte to get silylated diagnostic products during pyrolysis in gas chromatography- mass spectrometry.

Solubility
Miscible with methanol, ethyl ether, chloroform and benzene. Immiscible with water.

Notes
Incompatible with strong oxidizing agents and strong acids.

RUO – Research Use Only

General References:

Convenient, mild silylating reagent which generates gaseous ammonia as the only by-product (see Appendix 4). Non-acidic substrates normally require a catalyst.
Silylation of alcohols, including carbohydrates, is catalyzed by TMS chloride: J. Org. Chem., 23, 50 (1958); J. Am. Chem. Soc., 85, 2497 (1963); Chem. Ind. (London), 794 (1984). Silylation of phenols occurs readily, see also: Liebigs Ann. Chem., 20 (1973).
HMDS in the presence of TMS chloride permits the selective O-silylation of amino alcohols: Synthesis, 990 (1988). Alcohols and phenols can be silylated in the presence of amines and thiols with ZnCl₂ as catalyst: Synth. Commun., 23, 1633 (1993).
For conversion of carbonyl groups to silyl enol ethers, see Iodotrimethyl silane, A12902.
A range of catalysts for silylation with HMDS, including saccharin and sodium saccharin, has been recommended: J. Org. Chem., 47, 3966 (1982), for silylation of alcohols, phenols, thiols, carboxylic acids, amides, thioamides, hydroxamic acids, hydrazides, NH-groups of heterocycles, hydrazines, 1,3-diketones, etc. The use of TBAF (0.02 eq.) or iodine (0.01 eq.) also provide mild procedures for O-silylation: Tetrahedron Lett., 35, 8409 (1994); J. Org. Chem., 65, 7228 (2000).
Can also function as a protected form of ammonia, e.g. to convert acid chlorides to primary amides: Synthesis, 517 (1985), and substituted maleic anhydrides to maleimides: Tetrahedron Lett., 31, 5201 (1990).
In combination with DMSO, thiols are oxidized to disulfides under nearly neutral conditions: Synlett, 346 (2002).
The Na, Li and K derivatives are useful strong bases; see Sodium bis(trimethyl silyl) amide, L13352, Lithium bis(trimethyl silyl) amide, L15012, and Potassium bis(trimethyl silyl) amide, L15022.