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Proteintech
KAT5 Polyclonal Antibody
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Product Details
10827-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KAT5 Fusion Protein Ag1261 (101-457 aa encoded by BC000166)
Conjugate
Form
Liquid
Concentration
0.43 mg/mL
Amount
64.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ATPVPSETA PASVFPQNGA ARRAVAAQPG RKRKSNCLGT DEDSQDSSDG IPSAPRMTGS LVSDRSHDDI VTRMKNIECI ELGRHRLKPW YFSPYPQELT TLPVLYLCEF CLKYGRSLKC LQRHLTKCDL RHPPGNEIYR KGTISFFEID GRKNKSYSQN LCLLAKCFLD HKTLYYDTDP FLFYVMTEYD CKGFHIVGYF SKEKESTEDY NVACILTLPP YQRRGYGKLL IEFSYELSKV EGKTGTPEKP LSDLGLLSYR SYWSQTILEI LMGLKSESGE RPQITINEIS EITSIKKEDV ISTLQYLNLI NYYKGQYILT LSEDIVDGHE RAMLKRLLRI DSKCLHFTPK DWSKRGKW (101-457 aa encoded by BC000166)
Target Information
TIP60 is a transcription factor, originally isolated as an HIV-1 TAT-interactive protein, known to interact with the viral TAT protein that leads to HTATIP polyubiquitination and targets it for degradation. It belongs to the MYST family of histone acetyl transferases (HATs). TIP60 is a catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. A co-regulator of transcription factors, TIP60 either promotes or suppresses tumorigenesis. TIP60 is an enzyme that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 60 kDa Tat-interactive protein; cPLA(2)-interacting protein; cPLA2 interacting protein; Histone acetyltransferase HTATIP; Histone acetyltransferase KAT5; HIV-1 Tat interactive protein; HIV-1 tat interactive protein 1, 60 kDa homolog; HIV-1 tat interactive protein 1, homolog; HIV-1 Tat interactive protein 60 kD; HIV-1 Tat interactive protein, 60 kD; HIV-1 Tat interactive protein, 60kDa; HIV-1 tat interactive protein, homolog; K(lysine) acetyltransferase 5; K-acetyltransferase 5; Lysine acetyltransferase 5; Protein 2-hydroxyisobutyryltransferase KAT5; Protein acetyltransferase KAT5; Protein crotonyltransferase KAT5; Protein lactyltransferase KAT5; Tat interacting protein, 60kDa; Tat-interactive protein-60; Tip60; TIP60(HTATIP); unnamed protein product
Gene Aliases: AI839539; CPLA2; ESA1; HTATIP; HTATIP1; KAT5; NEDFASB; PLIP; TIP; Tip55; TIP60; Tip60b; ZC2HC5
UniProt ID: (Human) Q92993, (Mouse) Q8CHK4, (Rat) Q99MK2
Entrez Gene ID: (Human) 10524, (Mouse) 81601, (Rat) 192218
chromatin binding
transcription coactivator activity
histone acetyltransferase activity
protein binding
zinc ion binding
H4 histone acetyltransferase activity
acetyltransferase activity
transferase activity
transferase activity, transferring acyl groups
H2A histone acetyltransferase activity
histone H2AK5 acetyltransferase activity
metal ion binding
histone acetyltransferase activity (H4-K16 specific)
peptide-lysine-N-acetyltransferase activity
peptide 2-hydroxyisobutyryltransferase activity
peptide lactyltransferase (CoA-dependent) activity
peptide crotonyltransferase activity
peptide butyryltransferase activity
DNA-binding transcription factor binding
transcription factor binding
transferase activity, transferring acyl groups other than amino-acyl groups
protein complex binding
phospholipase binding
repressing transcription factor binding
histone modifying enzyme
negative regulation of transcription from RNA polymerase II promoter
establishment of mitotic spindle orientation
double-strand break repair via homologous recombination
DNA double-strand break processing
immune system process
DNA repair
nucleotide-excision repair
double-strand break repair
double-strand break repair via nonhomologous end joining
chromatin organization
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
phosphatidylethanolamine biosynthetic process
phosphatidylcholine biosynthetic process
apoptotic process
cellular response to DNA damage stimulus
spermatid development
response to ionizing radiation
regulation of autophagy
positive regulation of autophagy
positive regulation of triglyceride biosynthetic process
peptidyl-lysine acetylation
triglyceride biosynthetic process
neural tube development
neurogenesis
DNA damage response, signal transduction by p53 class mediator
negative regulation of interleukin-2 production
cellular response to stress
sperm chromatin condensation
aggrephagy
cellular response to glucose starvation
positive regulation of circadian rhythm
regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
innate immune response
positive regulation of innate immune response
positive regulation of regulatory T cell differentiation
negative regulation of myoblast differentiation
positive regulation of myoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
attachment of mitotic spindle microtubules to kinetochore
regulation of cell cycle
positive regulation of mitotic sister chromatid segregation
protein targeting to vacuole involved in autophagy
cellular response to glucose stimulus
cellular response to estradiol stimulus
cellular senescence
membraneless organelle assembly
DNA repair-dependent chromatin remodeling
cGAS/STING signaling pathway
cellular response to oxygen-containing compound
positive regulation of protein acetylation
regulation of hematopoietic stem cell differentiation
positive regulation of attachment of mitotic spindle microtubules to kinetochore
positive regulation of double-strand break repair via homologous recombination
positive regulation of aggrephagy
lipid droplet disassembly
protein localization to site of double-strand break
negative regulation of double-strand break repair via homologous recombination
regulation of double-strand break repair
transcription, DNA-templated
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
chromatin modification
histone acetylation
regulation of growth
response to heat
histone H4 acetylation
cellular response to hydrogen peroxide
cellular response to X-ray
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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