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Proteintech
BHLHE41 Polyclonal Antibody
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Product Details
12688-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BHLHE41 Fusion Protein Ag3381 (1-352 aa encoded by BC025968)
Conjugate
Form
Liquid
Concentration
0.16 mg/mL
Amount
24 µg
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDEGIPHLQ ERQLLEHRDF IGLDYSSLYM CKPKRSMKRD DTKDTYKLPH RLIEKKRRDR INECIAQLKD LLPEHLKLTT LGHLEKAVVL ELTLKHLKAL TALTEQQHQK IIALQNGERS LKSPIQSDLD AFHSGFQTCA KEVLQYLSRF ESWTPREPRC VQLINHLHAV ATQFLPTPQL LTQQVPLSKG TGAPSAAGSA AAPCLERAGQ KLEPLAYCVP VIQRTQPSAE LAAENDTDTD SGYGGEAEAR PDREKGKGAG ASRVTIKQEP PGEDSPAPKR MKLDSRGGGS GGGPGGGAVA AAAALLGPDP AAAAALLRPD AALLSSLVAF GGGGGAPFPQ PAAAAAPFCL PFC (1-352 aa encoded by BC025968)
Target Information
The BHLHE41 gene encodes a basic helix-loop-helix (bHLH) transcription factor located at the 12p12.1 susceptibility locus. It functions primarily as a nuclear transcriptional repressor, homodimerizing or heterodimerizing with various partners to regulate gene expression. BHLHE41 expression is highly tissue-specific and responsive to environmental cues. Genetic studies have highlighted its role in increasing xenograft tumor growth and its involvement in short sleep phenotypes. A notable mutation in BHLHE41 leads to a phenotype requiring only six hours of sleep, demonstrating its influence on sleep patterns. Moreover, BHLHE41 has been associated with osteoclast differentiation processes, indicating its involvement in cellular development. Its interaction with TFEB target genes suggests a protective role against certain types of cell death, emphasizing its complex role in cellular physiology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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