Search
元素の検索
構造の検索
Thermo Scientific Chemicals
Bacitracin, potency min. 60 Units/mg
Bacitracin, CAS # 1405-87-4, is cyclic polypeptide-based antibiotic which exhibits activity against microbes causing pneumonia, skin, and eye infections.
化学物質識別子
CAS1405-87-4
IUPAC Name4-(2-{[2-(1-amino-2-methylbutyl)-4,5-dihydro-1,3-thiazol-4-yl]formamido}-4-methylpentanamido)-4-[(1-{[18-(3-aminopropyl)-12-benzyl-15-(butan-2-yl)-3-(carbamoylmethyl)-6-(carboxymethyl)-9-[(4H-imidazol-4-yl)methyl]-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclopentacosan-21-yl]carbamoyl}-2-methylbutyl)carbamoyl]butanoic acid zinc
Molecular FormulaC66H103N17O16SZn
InChI KeyQSNOBVJFKSQBBD-UHFFFAOYNA-N
SMILES[Zn].CCC(C)C(N)C1=NC(CS1)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(C(C)CC)C(=O)NC1CCCCNC(=O)C(CC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(CC2C=NC=N2)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(NC(=O)C(CCCN)NC1=O)C(C)CC
さらに表示
仕様
スペックシート
スペックシートSulfated ash=<1.0 %
Composition>=40 % (Bacitracin A)
Composition>=70 % (sum of Bacitracin A, B1, B2 and B3)
Appearance (Color)White to yellow to beige
Appearance (Form)Powder
さらに表示
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Bacitracin is a mixture of at least nine different cyclic polypeptides, originally isolated from Bacillus bacteria in 1945
• Bacitracins work by binding divalent metal cations and preventing the hydrolysis of lipids into usable cell wall components
Applications
• Bacitracin has been paired with nanoparticles in some laboratory studies to increase its effectivity
• It is suitable for the laboratory study of bacterial resistance, infection, and cross-reactivity
RUO – Research Use Only
Literature References
Tay, W.M.; Epperson, J.D.; da Silva, G.F.; Ming, L.J. 1H NMR, mechanism, and mononuclear oxidative activity of the antibiotic metallopeptide bacitracin: the role of D-Glu-4, interaction with pyrophosphate moiety, DNA binding and cleavage, and bioactivity. J Am Chem Soc. 2010, 28, 132(16), 5652-61.
Karala, A.R.; Ruddock, L.W. Bacitracin is not a specific inhibitor of protein disulfide isomerase. FEBS J. 2010, 277(11), 2454-62.