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Proteintech
WIPI1 Polyclonal Antibody
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Product Details
25204-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
WIPI1 Fusion Protein Ag18461 (346-446 aa encoded by BC039867)
Conjugate
Form
Liquid
Concentration
0.38 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: QDGGECVLI KTHSLLGSGT TEENKENDLR PSLPQSYAAT VARPSASSAS TVPGYSEDGG ALRGEVIPEH EFATGPVCLD DENEFPPIIL CRGNQKGKTK QS (346-446 aa encoded by BC039867)
Target Information
WIPI1 (WD repeat domain, phosphoinositide interacting-1), also known as WIPI1, ATG18 or WIPI49, is thought to play a role in autophagy and may regulate protein trafficking in certain recycling pathways. It contains three WD repeats and has a 7-bladed propeller structure with a conserved motif that facilitates its interaction with other proteins. WIPI1 localizes to cytoplasmic vesicles, endosomes, clathrin-coated vesicles and the trans-Golgi network. It is ubiquitously expressed with highest expression in heart, testis, placenta, pancreas and skeletal muscle. WIPI1 is upregulated in a variety of tumors, suggesting a role in carcinogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Atg18 protein homolog; unnamed protein product; WD repeat domain phosphoinositide-interacting protein 1; WD40 repeat protein interacting with phosphoinositides of 49 kDa; WD40 repeat protein Interacting with phosphoInositides of 49kDa; WIPI 49 kDa; WIPI-1; WIPI-1 alpha; WIPI49; WD-repeat protein; 7-bladed beta propeller
Gene Aliases: 4930533H01Rik; ATG18; ATG18A; AW411817; D11Ertd498e; WIPI1; WIPI49
UniProt ID: (Human) Q5MNZ9, (Mouse) Q8R3E3
Entrez Gene ID: (Human) 55062, (Mouse) 52639
autophagosome assembly
mitophagy
pexophagy
autophagy
cellular response to starvation
protein localization to pre-autophagosomal structure
nucleophagy
vesicle targeting, trans-Golgi to endosome
glycophagy
positive regulation of autophagosome assembly
protein lipidation
cellular response to nitrogen starvation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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