A systematic quantification of carbonic anhydrase transcripts in the mouse digestive system.
AuthorsPan PW, Rodriguez A, Parkkila S
JournalBMC Mol Biol
PubMed ID17362527
'Carbonic anhydrases (CAs) are physiologically important enzymes which participate in many gastrointestinal processes such as acid and bicarbonate secretion and metabolic pathways including gluconeogenesis and ureagenesis. The genomic data suggests that there are thirteen enzymatically active members of the mammalian CA isozyme family. In the present study, we systematically examined ... More
Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination.
AuthorsStams T, Chen Y, Boriack-Sjodin PA, Hurt JD, Liao J, May JA, Dean T, Laipis P, Silverman DN, Christianson DW
JournalProtein Sci
PubMed ID9541386
'Carbonic anhydrase IV (CAIV) is a membrane-associated enzyme anchored to plasma membrane surfaces by a phosphatidylinositol glycan linkage. We have determined the 2.8-angstroms resolution crystal structure of a truncated, soluble form of recombinant murine CAIV. We have also determined the structure of its complex with a drug used for glaucoma ... More
Genomic organization and localization of gene for human carbonic anhydrase IV to chromosome 17q.
AuthorsOkuyama T, Batanian JR, Sly WS
JournalGenomics
PubMed ID8325641
Carbonic anhydrase IV (CA IV) is a glycosylphosphatidylinositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and on the luminal surface of proximal renal tubules. It is of interest for its functional importance in CO2 and HCO3- transport, its ancient evolutionary status among CA isozymes, ... More