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Thermo Scientific Chemicals
2-Amino-4,6-dichloropyrimidine, 98%
CAS: 56-05-3 | C4H3Cl2N3 | 163.989 g/mol
化学物質識別子
CAS56-05-3
IUPAC Name4,6-dichloropyrimidin-2-amine
Molecular FormulaC4H3Cl2N3
InChI KeyJPZOAVGMSDSWSW-UHFFFAOYSA-N
SMILESNC1=NC(Cl)=CC(Cl)=N1
さらに表示
仕様
スペックシート
スペックシートAppearance (Color)Pale cream
Melting Point (clear melt)218.0-225.0?C
Assay (GC)≥97.5%
FormPowder
Microwave-assisted synthesis of pyrazolo [3, 4-d] pyrimidines from 2-amino-4, 6-dichloropyrimidine-5-carbaldehyde is under solvent-free conditions. A series of 6-alkynyl-2,4-diaminopyrimidine derivatives bearing various substituents at alkynyl moiety was prepared by the Sonogashira cross-coupling reaction of 2,4-diamino-6-iodopyrimidine using Pd(PPh3)2Cl2 as catalyst.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Microwave-assisted synthesis of pyrazolo [3, 4-d] pyrimidines from 2-amino-4, 6-dichloropyrimidine-5-carbaldehyde is under solvent-free conditions. A series of 6-alkynyl-2,4-diaminopyrimidine derivatives bearing various substituents at alkynyl moiety was prepared by the Sonogashira cross-coupling reaction of 2,4-diamino-6-iodopyrimidine using Pd(PPh3)2Cl2 as catalyst.
Solubility
Insoluble in water, soluble in acetone, two monomer (VCM) and thermal toluene.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.
Microwave-assisted synthesis of pyrazolo [3, 4-d] pyrimidines from 2-amino-4, 6-dichloropyrimidine-5-carbaldehyde is under solvent-free conditions. A series of 6-alkynyl-2,4-diaminopyrimidine derivatives bearing various substituents at alkynyl moiety was prepared by the Sonogashira cross-coupling reaction of 2,4-diamino-6-iodopyrimidine using Pd(PPh3)2Cl2 as catalyst.
Solubility
Insoluble in water, soluble in acetone, two monomer (VCM) and thermal toluene.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.
RUO – Research Use Only
General References:
- Dana Hocková,; Antonın Holý,; Milena Masojıdková,; Ivan Votruba. An efficient synthesis of cytostatic mono and bis-alkynylpyrimidine derivatives by the Sonogashira cross-coupling reactions of 2,4-diamino-6-iodopyrimidine and 2-amino-4,6-dichloropyrimidine. Tetrahedron. 2004, 60 (23), 4983-4987.
- C. J. B. Clews,; W. Cochran. The structures of pyrimidines and purines. I. A determination of the structures of 2-amino-4-methyl-6-chloropyrimidine and 2-amino-4,6-dichloropyrimidine by X-ray methods . Acta Cryst.. 1948, 14-11.