1,4-Dimethoxybenzene is used as Pharmaceutical Intermediate. It is used in some paints and as a diazo dye. It is also used in perfumes and flavors in order to its floral odor. In addition, it is used on greasy skin, and with sulfur to treat acne, or as a dandruff treatment.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
1,4-Dimethoxybenzene is used as Pharmaceutical Intermediate. It is used in some paints and as a diazo dye. It is also used in perfumes and flavors in order to its floral odor. In addition, it is used on greasy skin, and with sulfur to treat acne, or as a dandruff treatment.
Solubility
Soluble in water(0.83g/L at 20°C) and methanol.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.
RUO – Research Use Only
General References:
- T. H. Goodwin.; M. Przybylska.; J. M. Robertson. The crystal and molecular structure of 1:4-dimethoxybenzene. Acta Cryst. 1950, 3 279-284.
- Dötterl Stefan.; Ulrike Füssel.; Andreas Jürgens.; Gregor Aas. 1, 4-Dimethoxybenzene, a floral scent compound in willows that attracts an oligolectic bee. Journal of chemical ecology. 2005, 31 (12), 2993-2998.
- In contrast to the 1,3-isomer (see preceding entry), direct dilithiation with n-BuLi/TMEDA was successful, giving, with TMS chloride, the 2,5-disilyl derivative in 68% yield: J. Org. Chem., 49, 4657 (1984).
- 1,4-Dimethoxybenzene and its simple derivatives undergo anodic oxidation in methanol, to give bis-acetals of benzoquinones. For experimental details, see: Org. Synth. Coll., 6, 971 (1988).
- For a review of the chemistry of these bis-acetals and of the mono-acetals obtained by partial hydrolysis, see: Acc. Chem. Res., 16, 74 (1983).