Search
元素の検索
構造の検索
Thermo Scientific Chemicals
Methyl acetoacetate, 99%
CAS: 105-45-3 | C5H8O3 | 116.12 g/mol
化学物質識別子
CAS105-45-3
IUPAC Namemethyl 3-oxobutanoate
Molecular FormulaC5H8O3
InChI KeyWRQNANDWMGAFTP-UHFFFAOYSA-N
SMILESCOC(=O)CC(C)=O
さらに表示
仕様
スペックシート
スペックシートAppearance (Color)Clear colorless
Assay (Silylated GC)≥98.5%
Refractive Index1.4175-1.4215 @ 20?C
FormLiquid
Methyl acetoacetate is used as a chemical reagent used in the synthesis of pharmaceuticals. It participates in the Biginelli reaction, forming molecules including dihydropyrimidinones.Methyl acetoacetate (MAA) is used for the synthesis of alpha-substituted aceto- acetic esters and cyclic compounds, e.g. pyrazole, pyrimidine and coumarin derivatives.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Methyl acetoacetate is used as a chemical reagent used in the synthesis of pharmaceuticals. It participates in the Biginelli reaction, forming molecules including dihydropyrimidinones.Methyl acetoacetate (MAA) is used for the synthesis of alpha-substituted aceto- acetic esters and cyclic compounds, e.g. pyrazole, pyrimidine and coumarin derivatives.
Solubility
Soluble in water
Notes
Store at 2-8°C. Incompatible with oxidizing agents and bases. Protect from light.
Methyl acetoacetate is used as a chemical reagent used in the synthesis of pharmaceuticals. It participates in the Biginelli reaction, forming molecules including dihydropyrimidinones.Methyl acetoacetate (MAA) is used for the synthesis of alpha-substituted aceto- acetic esters and cyclic compounds, e.g. pyrazole, pyrimidine and coumarin derivatives.
Solubility
Soluble in water
Notes
Store at 2-8°C. Incompatible with oxidizing agents and bases. Protect from light.
RUO – Research Use Only
General References:
- Michael M. Folkendt; Boris E. Weiss-Lopez; J. Paul ChauvelJr; Nancy S. True. Gas-phase proton NMR studies of keto-enol tautomerism of acetylacetone, methyl acetoacetate, and ethyl acetoacetate.J. Phys. Chem.1985, 89 (15), 3347-3352.
- Mark A. Keane; Geoffrey Webb. The enantioselective hydrogenation of methyl acetoacetate over supported nickel catalysts: I. The modification procedure.Journal of Catalysis.1992, 136 1-15.