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Thermo Scientific Chemicals
Azelaic acid, tech. 80%
CAS: 123-99-9 | C9H16O4 | 188.223 g/mol
化学物質識別子
CAS123-99-9
IUPAC Namenonanedioic acid
Molecular FormulaC9H16O4
InChI KeyBDJRBEYXGGNYIS-UHFFFAOYSA-N
SMILESOC(=O)CCCCCCCC(O)=O
さらに表示
仕様
スペックシート
スペックシートAppearance (Color)White to cream or pale yellow
FormCrystalline powder or flakes
Assay (Aqueous acid-base Titration)≥97.0% (total isomers)
Assay (Silylated GC)≥75.0%
Identification (FTIR)Conforms
It is applied in organic synthesis, lacquers, polyester adhesives, and urethane elastomers. Azelaic acid directly inhibits kallikrein 5 (KLK5), down regulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and up regulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPAR? is thought to drive these effects. Azelaic acid also inhibits proliferation of melanocytes.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Notes
Store away from strong oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
Store away from strong oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
RUO – Research Use Only
General References:
- M.R. Gasco, et al. In vitro permeation of azelaic acid from viscosized microemulsions.Int. J. Pharm.,1991,69(3), 193-196.
- Graupe K, et al. Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports.European Pubmed.,1996,57 (1), 20-35.