It is applied in organic synthesis, lacquers, polyester adhesives, and urethane elastomers. Azelaic acid directly inhibits kallikrein 5 (KLK5), down regulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and up regulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPAR? is thought to drive these effects. Azelaic acid also inhibits proliferation of melanocytes.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.