Chenodeoxycholic acid, Thermo Scientific Chemicals

Name: Chenodeoxycholic acid, Thermo Scientific Chemicals
SKU: J60364.06

Bile acid that induces apoptosis through protein kinase C signaling pathways

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数量:

5 g

25 g

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製品番号（カタログ番号） J60364.06

または、製品番号J60364-06

価格（JPY）

数量:

5 g

一括またはカスタム形式をリクエストする

化学物質識別子

CAS474-25-9

IUPAC Name(4R)-4-[(1R,3aS,3bR,4R,5aS,7R,9aS,9bS,11aR)-4,7-dihydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]pentanoic acid

Molecular FormulaC24H40O4

InChI KeyRUDATBOHQWOJDD-BSWAIDMHSA-N

SMILES[H][C@@]12CC[C@H]([C@H](C)CCC(O)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])[C@H](O)C[C@]2([H])C[C@H](O)CC[C@]12C

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仕様

スペックシート

Assay (unspecified)97.0% min.

Loss on Drying2.0% max.

Optical Rotation+10? to +13? (c=2 in ethanol)

Chenodeoxycholic acid is a bile acid that induces apoptosis through protein kinase C signaling pathways.Chenodeoxycholic acid is widely utilized in therapeutic applications. It is applied in medical therapy to dissolve gallstones. It is employed in the treatment of cerebrotendineous xanthomatosis. It is used to treat constipation and cerebrotendineous xanthomatosis. It acts as a urea receptor in supramolecular chemistry which can contain anions. It is a staining additive commonly used with ruthenium or organic photo-sensitizers in the preparation of staining solutions for dye solar cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in water, dimethyl sulfoxide, ethanol and dimethylformamide.

Notes
Incompatible with strong oxidizing agents.

RUO – Research Use Only

General References:

Zhang, Y.; Qu, H.; Feng, H.; Wang, X.; Shan, W.; Zeng, W.; Wang, Q.; Zhao, Y. Development of an enzyme-linked immunosorbent assay for chenodeoxycholic acid using an anti-chenodeoxycholic acid monoclonal antibody. Anal. Methods 2015, 7 (11), 4583-4589.
Jones, R. D.; Lopez, A. M.; Tong, E. Y.; Posey, K. S.; Chuang, J. C.; Repa, J. J.; Turley, S. D. Impact of physiological levels of chenodeoxycholic acid supplementation on intestinal and hepatic bile acid and cholesterol metabolism in Cyp7a1-deficient mice. Steroids 2015, 93, 87-95.