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Dexamethasone 21-phosphate disodium salt, 98%
Dexamethasone 21-phosphate disodium salt, 98%
Dexamethasone 21-phosphate disodium salt, 98%
Thermo Scientific Chemicals

Dexamethasone 21-phosphate disodium salt, 98%

Dexamethasone 21-phosphate disodium salt, CAS # 2392-39-4, is a synthetic adrenal glucocorticoid with potent anti-inflammatory activity. | CAS: 2392-39-4 | C22H28FNa2O8P | 516.41 g/mol
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数量:
1 g
5 g
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製品番号（カタログ番号） J64083.03
または、製品番号J64083-03
価格（JPY）
-
数量:
1 g
一括またはカスタム形式をリクエストする
化学物質識別子
CAS2392-39-4
IUPAC Namedisodium (1R,2R,3aS,3bS,9aS,9bR,10S,11aS)-9b-fluoro-1,10-dihydroxy-2,9a,11a-trimethyl-1-[2-(phosphonatooxy)acetyl]-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
Molecular FormulaC22H28FNa2O8P
InChI KeyPLCQGRYPOISRTQ-FCJDYXGNSA-L
SMILES[Na+].[Na+].C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP([O-])([O-])=O
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仕様Specification Sheetスペックシート
Appearance (Color)White to pale cream
FormCrystals or powder or crystalline powder
Assay from Suppliers CofA≥97.5%
Dexamethasone 21-phosphate disodium salt acts as an inducer of apoptosis and inhibitor of the sodium phosphate symporter. It is used in the treatment of emetic effects of cancer therapy and epicondylitis. Further, it serves as an activator of food, medicine, glucocorticoid and anti inflammatory.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Dexamethasone 21-phosphate disodium salt is a sodium phosphate salt form of dexamethasone, considered to be a synthetic adrenal glucocorticoid with anti-inflammatory activity

Application

  • Dexamethasone 21-phosphate disodium salt binds to specific nuclear steroid receptors, interfering with NF-kB activation and apoptotic pathways
  • It acts as an inducer of apoptosis and inhibitor of the sodium phosphate symporter
  • It has been used as a positive control to study its effects on ocular shedding of herpes simplex virus type 1 in the induced reactivation and spontaneous shedding rabbit models
  • This compound is used to study its protective effects against cisplatin-induced ototoxicity in the inner ear of guinea pigs
RUO – Research Use Only

General References:

  1. Keeler, G.D.; Durdik, J.M.; Stenken, J.A. Localized delivery of dexamethasone-21-phosphate via microdialysis implants in rat induces M(GC) macrophage polarization and alters CCL2 concentrations. Acta Biomater. 2015, 12, 11-20.
  2. Keeler, G. D.; Durdik, J. M.; Stenken, J. A. Effects of delayed delivery of dexamethasone-21-phosphate via subcutaneous microdialysis implants on macrophage activation in rats. Acta Biomater. 2015, 23, 27-37.
  3. Daldal, A., Odabasi, O.; Serbetcioglu, B. The protective effect of intratympanic dexamethasone on cisplatin-induced ototoxicity in guinea pigs. Otolaryngol Head Neck Surg. 2007, 137, (5), 747-52.
  4. Ogawa, N.; Kanki, K.; Honda, K.; Tomooka, Y.; Ryoke, K.; Watanabe, T. Involvement of glucocorticoid in induction of lingual T1R3 in rodents. Eur. J. Pharmacol. 2015, 761, 262-267.